V
Valeria Tosello
Researcher at Columbia University
Publications - 42
Citations - 2996
Valeria Tosello is an academic researcher from Columbia University. The author has contributed to research in topics: T cell & Leukemia. The author has an hindex of 21, co-authored 41 publications receiving 2734 citations.
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Journal ArticleDOI
γ-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia
Pedro J. Real,Valeria Tosello,Teresa Palomero,Teresa Palomero,Mireia Castillo,Eva Hernando,Elisa de Stanchina,Maria Luisa Sulis,Maria Luisa Sulis,Kelly Barnes,Catherine M. Sawai,Irene Homminga,Jules P.P. Meijerink,Iannis Aifantis,Giuseppe Basso,Carlos Cordon-Cardo,Weiyun Z. Ai,Adolfo A. Ferrando,Adolfo A. Ferrando +18 more
TL;DR: It is shown that combination therapy with GSIs plus glucocorticoids can improve the antileukemic effects of GSIs and reduce their gut toxicity in vivo and support a role for glucocORTicoid-resistant T-ALL.
Journal ArticleDOI
Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL.
Gannie Tzoneva,Arianne Perez-Garcia,Zachary Carpenter,Hossein Khiabanian,Valeria Tosello,Maddalena Allegretta,Elisabeth Paietta,Janis Racevskis,Jacob M. Rowe,Jacob M. Rowe,Martin S. Tallman,Maddalena Paganin,Giuseppe Basso,Jana Hof,Renate Kirschner-Schwabe,Teresa Palomero,Raul Rabadan,Adolfo A. Ferrando +17 more
TL;DR: A prominent role for activating mutations in NT5C2 and increased nucleoside-analog metabolism in disease progression and chemotherapy resistance in ALL is supported.
Journal ArticleDOI
Vaccination with NY-ESO-1 protein and CpG in Montanide induces integrated antibody/Th1 responses and CD8 T cells through cross-priming.
Danila Valmori,Naira E. Souleimanian,Valeria Tosello,Nina Bhardwaj,Sylvia Adams,David O'Neill,Anna C. Pavlick,J. Escalon,Crystal M. Cruz,Angelica Angiulli,Francesca Angiulli,Gregory Mears,Susan M. Vogel,Linda Pan,Achim A. Jungbluth,Eric Hoffmann,Ralph Venhaus,Gerd Ritter,Lloyd J. Old,Maha Ayyoub,Maha Ayyoub +20 more
TL;DR: Recombinant NY-ESO-1 protein, Montanide ISA-51, and CpG ODN 7909, a potent stimulator of B cells and T helper type 1 (Th1)-type immunity, resulted in the early induction of specific integrated CD4+ Th cells and antibody responses in most vaccinated patients, followed by the development of later CD8+ T cell responses in a fraction of them.
Journal ArticleDOI
Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemia
Erich Piovan,Erich Piovan,Jiyang Yu,Valeria Tosello,Daniel Herranz,Alberto Ambesi-Impiombato,Ana Carolina Da Silva,Marta Sanchez-Martin,Arianne Perez-Garcia,Isaura Rigo,Mireia Castillo,Stefano Indraccolo,Justin R. Cross,Elisa de Stanchina,Elisabeth Paietta,Elisabeth Paietta,Janis Racevskis,Janis Racevskis,Jacob M. Rowe,Martin S. Tallman,Giuseppe Basso,Jules P.P. Meijerink,Carlos Cordon-Cardo,Andrea Califano,Adolfo A. Ferrando +24 more
TL;DR: It is demonstrated that loss of PTEN and consequent AKT1 activation can effectively block glucocorticoid-induced apoptosis and induce resistance to glucoc Corticoid therapy, and pharmacologic inhibition of AKT with MK2206 effectively reverses glucocORTicoid resistance.
Journal ArticleDOI
Rapamycin-Mediated Enrichment of T Cells with Regulatory Activity in Stimulated CD4+ T Cell Cultures Is Not Due to the Selective Expansion of Naturally Occurring Regulatory T Cells but to the Induction of Regulatory Functions in Conventional CD4+ T Cells
Danila Valmori,Valeria Tosello,Naira E. Souleimanian,Emmanuelle Godefroy,Luigi Scotto,Yu Wang,Maha Ayyoub +6 more
TL;DR: Assessing the effect of rapamycin on the growth of nonregulatory and Treg populations of defined differentiation stages purified ex vivo from circulating CD4+ T cells shows that this phenomenon is not due to a selective expansion of naturally occurring Tregs, but to the capacity ofRapamycin to induce, upon TCR-mediated stimulation, suppressor functions in conventional CD4- T cells.