V
Vandana Gupta
Researcher at University of Delhi
Publications - 97
Citations - 3273
Vandana Gupta is an academic researcher from University of Delhi. The author has contributed to research in topics: Zebrafish & Skeletal muscle. The author has an hindex of 27, co-authored 88 publications receiving 2563 citations. Previous affiliations of Vandana Gupta include Johns Hopkins University & Brigham and Women's Hospital.
Papers
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Journal ArticleDOI
COVID-19 Vaccine: A comprehensive status report.
Simran Kaur,Vandana Gupta +1 more
TL;DR: The COVID-19 pandemic which probably is the most devastating one in the last 100 years after Spanish flu mandates the speedy evaluation of the multiple approaches for competence to elicit protective immunity and safety to curtail unwanted immune-potentiation which plays an important role in the pathogenesis of this virus.
Journal ArticleDOI
Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy
Michaela Yuen,Sarah A. Sandaradura,James J. Dowling,James J. Dowling,Alla S. Kostyukova,Natalia Moroz,Kate G. R. Quinlan,Vilma Lotta Lehtokari,Gianina Ravenscroft,Emily J. Todd,Ozge Ceyhan-Birsoy,David S. Gokhin,Jérome Maluenda,Monkol Lek,Monkol Lek,Flora Nolent,Christopher T. Pappas,Stefanie M. Novak,Adele D'Amico,Edoardo Malfatti,Brett Thomas,Brett Thomas,Stacey Gabriel,Namrata Gupta,Mark J. Daly,Mark J. Daly,Biljana Ilkovski,Peter J. Houweling,Peter J. Houweling,Ann E. Davidson,Ann E. Davidson,Lindsay C. Swanson,Catherine A. Brownstein,Vandana Gupta,Livija Medne,Patrick Shannon,Nicole Martin,David P. Bick,Anders Flisberg,Eva Holmberg,Peter Van den Bergh,Pablo Lapunzina,Leigh B. Waddell,Darcée D. Sloboda,Enrico Bertini,David Chitayat,William R. Telfer,Annie Laquerrière,Carol C. Gregorio,Coen A.C. Ottenheijm,Carsten G. Bönnemann,Katarina Pelin,Alan H. Beggs,Yukiko K. Hayashi,Norma B. Romero,Nigel G. Laing,Ichizo Nishino,Carina Wallgren-Pettersson,Judith Melki,Velia M. Fowler,Daniel G. MacArthur,Daniel G. MacArthur,Kathryn N. North,Kathryn N. North,Kathryn N. North,Nigel F. Clarke +65 more
TL;DR: It is demonstrated that mutations in the gene encoding L MOD3 underlie congenital myopathy and demonstrate that LMOD3 is essential for the organization of sarcomeric thin filaments in skeletal muscle.
Journal ArticleDOI
Exome Sequencing and Functional Validation in Zebrafish Identify GTDC2 Mutations as a Cause of Walker-Warburg Syndrome
M. Chiara Manzini,Dimira E. Tambunan,Dimira E. Tambunan,R. Sean Hill,R. Sean Hill,Timothy W. Yu,Timothy W. Yu,Thomas M. Maynard,Erin L. Heinzen,Kevin V. Shianna,Christine Stevens,Jennifer N. Partlow,Jennifer N. Partlow,Brenda J. Barry,Brenda J. Barry,Jacqueline Rodriguez,Jacqueline Rodriguez,Vandana Gupta,Abdel Karim Al-Qudah,Wafaa Eyaid,Jan M. Friedman,Jan M. Friedman,Mustafa A. Salih,Robin Clark,Isabella Moroni,Marina Mora,Alan H. Beggs,Stacey Gabriel,Christopher A. Walsh,Christopher A. Walsh,Christopher A. Walsh +30 more
TL;DR: It is found that gtdc2 knockdown in zebrafish replicates all WWS features (hydrocephalus, ocular defects, and muscular dystrophy), strongly suggesting that GTDC2 mutations cause WWS.
Journal ArticleDOI
Identification of KLHL41 Mutations Implicates BTB-Kelch-Mediated Ubiquitination as an Alternate Pathway to Myofibrillar Disruption in Nemaline Myopathy
Vandana Gupta,Gianina Ravenscroft,Ranad Shaheen,Emily J. Todd,Lindsay C. Swanson,Masaaki Shiina,Kazuhiro Ogata,Cynthia P. Hsu,Nigel F. Clarke,Basil T. Darras,Michelle A. Farrar,Amal M. Hashem,Nicholas Manton,Francesco Muntoni,Kathryn N. North,Sarah A. Sandaradura,Ichizo Nishino,Yukiko K. Hayashi,Caroline Sewry,Elizabeth Thompson,Elizabeth Thompson,Kyle S. Yau,Catherine A. Brownstein,Timothy W. Yu,Richard J.N. Allcock,Mark R. Davis,Carina Wallgren-Pettersson,Naomichi Matsumoto,Fowzan S. Alkuraya,Nigel G. Laing,Alan H. Beggs +30 more
TL;DR: These studies expand the genetic heterogeneity of NM and implicate a critical role of BTB-Kelch family members in maintenance of sarcomeric integrity in NM.
in Zebrafish Identify GTDC2 Mutations as a Cause of Walker-Warburg Syndrome
M. Chiara Manzini,Dimira E. Tambunan,R. Sean Hill,Timothy W. Yu,Thomas M. Maynard,Erin L. Heinzen,Kevin V. Shianna,Christine Stevens,Jennifer N. Partlow,Brenda J. Barry,Jacqueline Rodriguez,Vandana Gupta,Abdel-Karim Al-Qudah,Wafaa Eyaid,Jan M. Friedman,Mustafa A. Salih,Robin D. Clark,Isabella Moroni,Marina Mora,Alan H. Beggs,Stacey Gabriel,Christopher A. Walsh +21 more
TL;DR: In this paper, the authors combined whole-exome sequencing (WES) with homozygosity analysis of consanguineous pedigrees to identify genetic mutations responsible for Walker-Warburg syndrome (WWS), a genetically heterogeneous autosomal-recessive disorder that severely affects the development of the brain, eyes, and muscle.