V
Verena Raker
Researcher at University of Mainz
Publications - 36
Citations - 1085
Verena Raker is an academic researcher from University of Mainz. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 9, co-authored 24 publications receiving 811 citations.
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Journal ArticleDOI
Nutritional Wheat Amylase-Trypsin Inhibitors Promote Intestinal Inflammation via Activation of Myeloid Cells
Victor F. Zevallos,Verena Raker,Stefan Tenzer,Carolina Jimenez-Calvente,M. Ashfaq-Khan,Nina Rüssel,Geethanjali Pickert,Hansjörg Schild,Kerstin Steinbrink,Detlef Schuppan,Detlef Schuppan +10 more
TL;DR: Gluten-containing cereals have by far the highest concentrations of ATIs that activate TLR4, and orally ingested ATIs are largely resistant to proteases and heat, and increase intestinal inflammation by activating gut and mesenteric lymph node myeloid cells.
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Tolerogenic Dendritic Cells for Regulatory T Cell Induction in Man
TL;DR: An overview on efforts and protocols to generate human tolerogenic DCs with focus on IL-10-modulated DCs as inducers of Tregs is given and their clinical applications and challenges faced in further developing this form of immunotherapy are discussed.
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The cAMP Pathway as Therapeutic Target in Autoimmune and Inflammatory Diseases
TL;DR: An overview of the cyclic AMP axis and its role as a regulator of immune functions is provided and the clinical and translational relevance of interventions with these processes are discussed.
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Tolerance through Education: How Tolerogenic Dendritic Cells Shape Immunity.
TL;DR: This review gives an overview about methods and protocols for the generation of human tolerogenic DCs and their mechanisms of tolerance induction with the focus on interleukin-10-modulated DCs.
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Interferon-α Suppresses cAMP to Disarm Human Regulatory T Cells
Nicole Bacher,Verena Raker,Claudia Hofmann,Edith Graulich,Melanie Schwenk,Ria Baumgrass,Tobias Bopp,Ulrich Zechner,Luzie Merten,Christian Becker,Kerstin Steinbrink +10 more
TL;DR: It is shown that IFN-α deactivates the suppressive function of human Treg by downregulating their intracellular cAMP level, which provides a conceivable explanation for the immune-promoting effect and induction of autoimmunity by IFn-α treatment in patients with cancer and suggestsIFN- α for concomitant Treg blockade in the context of therapeutic vaccination against tumor antigens.