Nutritional Wheat Amylase-Trypsin Inhibitors Promote Intestinal Inflammation via Activation of Myeloid Cells
Victor F. Zevallos,Verena Raker,Stefan Tenzer,Carolina Jimenez-Calvente,M. Ashfaq-Khan,Nina Rüssel,Geethanjali Pickert,Hansjörg Schild,Kerstin Steinbrink,Detlef Schuppan,Detlef Schuppan +10 more
TLDR
Gluten-containing cereals have by far the highest concentrations of ATIs that activate TLR4, and orally ingested ATIs are largely resistant to proteases and heat, and increase intestinal inflammation by activating gut and mesenteric lymph node myeloid cells.About:
This article is published in Gastroenterology.The article was published on 2017-04-01 and is currently open access. It has received 237 citations till now. The article focuses on the topics: Mesenteric lymph nodes.read more
Citations
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Evolving role of diet in the pathogenesis and treatment of inflammatory bowel diseases
TL;DR: Progress in the field of microbiome and IBD has demonstrated that microbiome appears to play an important role in pathogenesis, and that diet may in turn impact the composition and functionality of the microbiome.
Journal ArticleDOI
Toll-like Receptors and Inflammatory Bowel Disease.
TL;DR: The purpose of this review article is to summarize the potential mechanisms of TLR signaling pathways in IBD and the novel potential therapeutic strategies against IBD.
Journal ArticleDOI
Air Pollution and Climate Change Effects on Allergies in the Anthropocene: Abundance, Interaction, and Modification of Allergens and Adjuvants
Kathrin Reinmuth-Selzle,Christopher J. Kampf,Kurt Lucas,Naama Lang-Yona,Janine Fröhlich-Nowoisky,Manabu Shiraiwa,Pascale S. J. Lakey,Senchao Lai,Fobang Liu,Anna T. Kunert,Kira Ziegler,Fangxia Shen,Rossella Sgarbanti,Bettina Weber,Iris Bellinghausen,Joachim Saloga,Michael G. Weller,Albert Duschl,Detlef Schuppan,Detlef Schuppan,Ulrich Pöschl +20 more
TL;DR: An overview of physical, chemical and biological interactions between air pollution, climate change, allergens, adjuvants and the immune system, addressing how these interactions may promote the development of allergies is provided.
Journal ArticleDOI
The Overlapping Area of Non-Celiac Gluten Sensitivity (NCGS) and Wheat-Sensitive Irritable Bowel Syndrome (IBS): An Update
Carlo Catassi,Armin Alaedini,Christian Bojarski,Bruno Bonaz,Gerd Bouma,Antonio Carroccio,Gemma Castillejo,Laura de Magistris,Walburga Dieterich,Diana Di Liberto,Luca Elli,Alessio Fasano,Marios Hadjivassiliou,Matthew Kurien,Elena Lionetti,Chris J. J. Mulder,Kamran Rostami,Anna Sapone,Katharina Anne Scherf,Detlef Schuppan,Nick Trott,Umberto Volta,Victor F. Zevallos,Yurdagül Zopf,David S Sanders +24 more
TL;DR: Clinicians are provided with an update that directly impacts on the management of a subgroup of their IBS patients whose symptoms are triggered by wheat ingestion.
Journal ArticleDOI
Genome mapping of seed-borne allergens and immunoresponsive proteins in wheat
Angéla Juhász,Angéla Juhász,Tatiana Belova,Chris Florides,Csaba Maulis,Iris Fischer,Gyöngyvér Gell,Zsófia Birinyi,Jamie Ong,Gabriel Keeble-Gagnère,Amudha Maharajan,Wujun Ma,Peter R. Gibson,Jizeng Jia,Daniel Lang,Klaus F. X. Mayer,Manuel Spannagl,Jason A. Tye-Din,Jason A. Tye-Din,Rudi Appels,Rudi Appels,Odd-Arne Olsen +21 more
TL;DR: A comprehensive analysis of variation in genes and gene expression of allergens and immunoresponsive proteins in wheat establishes a new reference map for immunostimulatory wheat proteins and provides a fresh basis for selecting wheat lines and developing diagnostics for products with more favorable consumer attributes.
References
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Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4
Yvonne Junker,Sebastian Zeissig,Seong-Jun Kim,Donatella Barisani,Donatella Barisani,Herbert Wieser,Daniel A. Leffler,Victor F. Zevallos,Towia A. Libermann,Simon T. Dillon,Tobias L. Freitag,Tobias L. Freitag,Ciaran P. Kelly,Detlef Schuppan,Detlef Schuppan +14 more
TL;DR: Pest resistance molecules, α-amylase/trypsin inhibitors from wheat, activate innate immune cells through engagement of TLR4 to elicit inflammatory responses in the intestine.
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Diagnosis of Non-Celiac Gluten Sensitivity (NCGS): The Salerno Experts’ Criteria
Carlo Catassi,Luca Elli,Bruno Bonaz,Gerd Bouma,Antonio Carroccio,Gemma Castillejo,Christophe Cellier,Fernanda Cristofori,Laura de Magistris,Jernej Dolinsek,Walburga Dieterich,Ruggiero Francavilla,Marios Hadjivassiliou,Wolfgang Holtmeier,Ute Körner,Daniel A. Leffler,Knut E.A. Lundin,Giuseppe Mazzarella,Chris J. J. Mulder,Nicoletta Pellegrini,Kamran Rostami,David S Sanders,Gry Irene Skodje,Detlef Schuppan,Reiner Ullrich,Umberto Volta,Marianne Williams,Victor F. Zevallos,Yurdagül Zopf,Alessio Fasano +29 more