N
Nicole M. Koropatkin
Researcher at University of Michigan
Publications - 67
Citations - 6746
Nicole M. Koropatkin is an academic researcher from University of Michigan. The author has contributed to research in topics: Bacteroides thetaiotaomicron & Starch. The author has an hindex of 30, co-authored 59 publications receiving 5070 citations. Previous affiliations of Nicole M. Koropatkin include University of Illinois at Urbana–Champaign & Donald Danforth Plant Science Center.
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Journal ArticleDOI
A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility
Mahesh Desai,Mahesh Desai,Anna M. Seekatz,Nicole M. Koropatkin,Nobuhiko Kamada,Christina A. Hickey,Mathis Wolter,Nicholas A. Pudlo,Sho Kitamoto,Nicolas Terrapon,Arnaud Muller,Vincent B. Young,Bernard Henrissat,Paul Wilmes,Thaddeus S. Stappenbeck,Gabriel Núñez,Eric C. Martens +16 more
TL;DR: Dietary fiber deprivation, together with a fiber-deprived, mucus-eroding microbiota, promotes greater epithelial access and lethal colitis by the mucosal pathogen, Citrobacter rodentium.
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How glycan metabolism shapes the human gut microbiota
TL;DR: How glycans shape the composition of the gut microbiota over various periods of time is described, the mechanisms by which individual microorganisms degrade these glycans, and potential opportunities to intentionally influence this ecosystem for better health and nutrition are described.
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Complex Glycan Catabolism by the Human Gut Microbiota: The Bacteroidetes Sus-like Paradigm*
TL;DR: This work reviews how members of the Bacteroidetes, one of two dominant gut-associated bacterial phyla, process complex glycans using a series of similarly patterned, cell envelope-associated multiprotein systems, providing insights into how gut, as well as terrestrial and aquatic, Bacteroids survive in highly competitive ecosystems.
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A discrete genetic locus confers xyloglucan metabolism in select human gut Bacteroidetes
Johan Larsbrink,Theresa E. Rogers,Glyn R. Hemsworth,Lauren S. McKee,Alexandra S. Tauzin,Oliver Spadiut,Stefan Klinter,Nicholas A. Pudlo,Karthik Urs,Nicole M. Koropatkin,A. Louise Creagh,Charles A. Haynes,Amelia G. Kelly,Stefan Nilsson Cederholm,Gideon J. Davies,Eric C. Martens,Harry Brumer +16 more
TL;DR: It is demonstrated that a single, complex gene locus in Bacteroides ovatus confers XyG catabolism in this common colonic symbiont, and the metabolism of even highly abundant components of dietary fibre may be mediated by niche species.
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Polysaccharide Degradation by the Intestinal Microbiota and Its Influence on Human Health and Disease
TL;DR: The molecular underpinnings of these polysaccharide degradation processes, their impact on human health, and how the authors can manipulate them through the use of prebiotics are summarized.