A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility
Mahesh Desai,Mahesh Desai,Anna M. Seekatz,Nicole M. Koropatkin,Nobuhiko Kamada,Christina A. Hickey,Mathis Wolter,Nicholas A. Pudlo,Sho Kitamoto,Nicolas Terrapon,Arnaud Muller,Vincent B. Young,Bernard Henrissat,Paul Wilmes,Thaddeus S. Stappenbeck,Gabriel Núñez,Eric C. Martens +16 more
TLDR
Dietary fiber deprivation, together with a fiber-deprived, mucus-eroding microbiota, promotes greater epithelial access and lethal colitis by the mucosal pathogen, Citrobacter rodentium.About:
This article is published in Cell.The article was published on 2016-11-17 and is currently open access. It has received 1689 citations till now. The article focuses on the topics: Gut flora & Microbiome.read more
Citations
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Introduction to the human gut microbiota
Elizabeth Thursby,Nathalie Juge +1 more
TL;DR: This review summarises the current understanding of the development and composition of the human GI microbiota, and its impact on gut integrity and host health, underlying the need for mechanistic studies focusing on host–microbe interactions.
Journal ArticleDOI
The Impact of Dietary Fiber on Gut Microbiota in Host Health and Disease.
TL;DR: This review will focus on dietary fibers, which interact directly with gut microbes and lead to the production of key metabolites such as short-chain fatty acids, and discuss how dietary fiber impacts gut microbial ecology, host physiology, and health.
Journal ArticleDOI
Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug
Hao Wu,Eduardo Esteve,Eduardo Esteve,Valentina Tremaroli,Muhammad Tanweer Khan,Robert Caesar,Louise Mannerås-Holm,Marcus Ståhlman,Lisa M. Olsson,Matteo Serino,Mercè Planas-Fèlix,Gemma Xifra,Gemma Xifra,Josep M. Mercader,David Torrents,David Torrents,Rémy Burcelin,Rémy Burcelin,Wifredo Ricart,Wifredo Ricart,Rosie Perkins,José Manuel Fernández-Real,José Manuel Fernández-Real,Fredrik Bäckhed,Fredrik Bäckhed,Fredrik Bäckhed +25 more
TL;DR: It is shown that metformin affected pathways with common biological functions in species from two different phyla, and many of the met formin-regulated genes in these species encoded metalloproteins or metal transporters, which provides support for the notion that altered gut microbiota mediates some of metformIn's antidiabetic effects.
Journal ArticleDOI
Role of the gut microbiota in nutrition and health
TL;DR: Ana M Valdes and colleagues discuss strategies for modulating the gut microbiota through diet and probiotics and suggest that a Mediterranean diet supplemented with probiotics can be a viable alternative to a probiotic regime.
Journal ArticleDOI
Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease.
TL;DR: Understanding the interaction of the microbiota with pathogens and the immune system will provide critical insight into the pathogenesis of disease and the development of strategies to prevent and treat inflammatory disease.
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