V
Vincent Zoete
Researcher at Swiss Institute of Bioinformatics
Publications - 155
Citations - 20005
Vincent Zoete is an academic researcher from Swiss Institute of Bioinformatics. The author has contributed to research in topics: T-cell receptor & T cell. The author has an hindex of 43, co-authored 135 publications receiving 12342 citations. Previous affiliations of Vincent Zoete include Ludwig Institute for Cancer Research & University of Lausanne.
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Defining and searching for structural motifs using DeepView/Swiss-PdbViewer
TL;DR: An extension of DeepView/Swiss-PdbViewer is described through which structural motifs may be defined and searched for in large protein structure databases, and it is shown that common structural motifS involved in stabilizing protein folds are present in evolutionarily and structurally unrelated proteins.
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Study of the insulin dimerization: binding free energy calculations and per-residue free energy decomposition.
TL;DR: The results show that the dimerization of insulin is mainly due to nonpolar interactions, and the role of the hydrogen bonds between the 2 monomers appears to give the direction of the interactions.
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Evidence for a TCR Affinity Threshold Delimiting Maximal CD8 T Cell Function
Daphné Schmid,Melita Irving,Vilmos Posevitz,Michael Hebeisen,Anita Posevitz-Fejfar,J-C. Floyd Sarria,Raquel Gomez-Eerland,Margot Thome,Ton N. Schumacher,Pedro Romero,Daniel E. Speiser,Vincent Zoete,Olivier Michielin,Olivier Michielin,Nathalie Rufer +14 more
TL;DR: It is proposed that rational design of improved self-specific TCRs may not need to be optimized beyond a given affinity threshold to achieve both optimal T cell function and avoidance of the unpredictable risk of cross-reactivity.
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SwissSimilarity: A Web Tool for Low to Ultra High Throughput Ligand-Based Virtual Screening.
TL;DR: Users can be carried out on-the-fly using six different screening approaches, including 2D molecular fingerprints as well as superpositional and fast nonsuperpositional 3D similarity methodologies to provide proficient virtual screening capabilities to specialists and nonexperts in the field.
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Challenges in the Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors
Ute F. Röhrig,Somi Reddy Majjigapu,Somi Reddy Majjigapu,Pierre Vogel,Pierre Vogel,Vincent Zoete,Olivier Michielin,Olivier Michielin,Olivier Michielin +8 more
TL;DR: Issues in the employed experimental protocols, review and classify reported IDO1 inhibitors, and suggest different approaches for confirming viable inhibitor scaffolds are described.