V
Vincent Zoete
Researcher at Swiss Institute of Bioinformatics
Publications - 155
Citations - 20005
Vincent Zoete is an academic researcher from Swiss Institute of Bioinformatics. The author has contributed to research in topics: T-cell receptor & T cell. The author has an hindex of 43, co-authored 135 publications receiving 12342 citations. Previous affiliations of Vincent Zoete include Ludwig Institute for Cancer Research & University of Lausanne.
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Journal ArticleDOI
Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma
Ximena Bonilla,Laurent Parmentier,Bryan W. King,Fedor Bezrukov,Fedor Bezrukov,Gürkan Kaya,Vincent Zoete,Vladimir B. Seplyarskiy,Vladimir B. Seplyarskiy,Vladimir B. Seplyarskiy,Hayley J. Sharpe,Thomas Alexander Mckee,Audrey Letourneau,Pascale Ribaux,Konstantin Popadin,Nicole Basset-Seguin,Rouaa Ben Chaabene,Federico Santoni,Maria A. Andrianova,Maria A. Andrianova,Maria A. Andrianova,Michel Guipponi,Marco Garieri,Carole Verdan,Kerstin Grosdemange,Olga Sumara,Martin Eilers,Iannis Aifantis,Olivier Michielin,Olivier Michielin,Frederic J. de Sauvage,Stylianos E. Antonarakis,Sergey Nikolaev +32 more
TL;DR: Functional analysis of the mutations in MYCN, PTPN14 and LATS1 suggested their potential relevance in BCC tumorigenesis, and the mutational profiles, N-Myc and Hippo-YAP pathway target genes were upregulated.
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Peroxisome proliferator-activated receptor structures: ligand specificity, molecular switch and interactions with regulators.
TL;DR: It is shown that the numerous experimental three-dimensional structures available help understanding the role played by the activating function-2 (AF-2) in PPARs activation and its underlying molecular mechanism.
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The Endocrine Disruptor Monoethyl-hexyl-phthalate Is a Selective Peroxisome Proliferator-activated Receptor γ Modulator That Promotes Adipogenesis
Jerome N. Feige,Laurent Gelman,Daniel Rossi,Vincent Zoete,Raphaël Métivier,Cicerone Tudor,Silvia I. Anghel,Aurélien Grosdidier,Caroline Lathion,Yves Engelborghs,Olivier Michielin,Walter Wahli,Béatrice Desvergne +12 more
TL;DR: Structural and functional analyses are performed that demonstrate how monoethyl-hexyl-phthalate (MEHP) directly activates PPARγ and promotes adipogenesis, albeit to a lower extent than the full agonist rosiglitazone.
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Shaping the interaction landscape of bioactive molecules.
TL;DR: This work shows that accurate target prediction can be achieved by combining different measures of chemical similarity based on both chemical structure and molecular shape and indicates that the combined approach is especially efficient when no ligand with the same scaffold or from the same chemical series has yet been discovered.
Journal ArticleDOI
Personalized cancer vaccine effectively mobilizes antitumor T cell immunity in ovarian cancer
Janos L. Tanyi,Sara Bobisse,Eran Ophir,Sandra Tuyaerts,Annalisa Roberti,Raphael Genolet,Petra Baumgartner,Brian Stevenson,Christian Iseli,Denarda Dangaj,Brian J. Czerniecki,Aikaterini Semilietof,Julien Racle,Julien Racle,Alexandra Michel,Ioannis Xenarios,Cheryl Lai-Lai Chiang,Dimitri S. Monos,Drew A. Torigian,Harvey L. Nisenbaum,Olivier Michielin,Olivier Michielin,Carl H. June,Bruce L. Levine,Daniel J. Powell,David Gfeller,David Gfeller,Rosemarie Mick,Urania Dafni,Vincent Zoete,Vincent Zoete,Alexandre Harari,George Coukos,George Coukos,Lana E. Kandalaft,Lana E. Kandalaft +35 more
TL;DR: It is concluded that the use of oxidized whole-tumor lysate DC vaccine is safe and effective in eliciting a broad antitumor immunity, including private neoantigens, and warrants further clinical testing.