V
Vincent Zoete
Researcher at Swiss Institute of Bioinformatics
Publications - 155
Citations - 20005
Vincent Zoete is an academic researcher from Swiss Institute of Bioinformatics. The author has contributed to research in topics: T-cell receptor & T cell. The author has an hindex of 43, co-authored 135 publications receiving 12342 citations. Previous affiliations of Vincent Zoete include Ludwig Institute for Cancer Research & University of Lausanne.
Papers
More filters
Journal ArticleDOI
Both APRIL and antibody-fragment-based CAR T cells for myeloma induce BCMA downmodulation by trogocytosis and internalization
TL;DR: A proliferation inducing ligand (APRIL) based dual-antigen targeting CARs was designed and characterized in this article , and mechanisms of resistance to CAR T cells with three different BCMA-binding moieties were investigated.
Journal ArticleDOI
Heterozygous variants in CTR9, which encodes a major component of the PAF1 complex, are associated with a neurodevelopmental disorder.
Marije E.C. Meuwissen,Aline Verstraeten,Emmanuelle Ranza,Justyna Iwaszkiewicz,Maaike Bastiaansen,Ligia Mateiu,Merlijn Nemegeer,Josephina A.N. Meester,Alexandra Afenjar,Michelle D. Amaral,Diana Ballhausen,Sarah Barnett,Magalie Barth,Bob Asselbergh,Katrien Spaas,Bavo Heeman,Jennifer A. Bassetti,Patrick Blackburn,Marie Schaer,Xavier Blanc,Vincent Zoete,Kari Casas,Thomas Courtin,Diane Doummar,Frédéric Guerry,Boris Keren,John Pappas,Rachel Rabin,Amber Begtrup,Marwan Shinawi,Anneke T. Vulto-van Silfhout,Tjitske Kleefstra,Matias Wagner,Alban Ziegler,Elise Schaefer,Bénédicte Gérard,Charlotte I. de Bie,Sjoerd J B Holwerda,M Abbot,Stylianos E. Antonarakis,Bart Loeys +40 more
TL;DR: A neurodevelopmental disorder caused by (mainly) de novo variants in CTR9, likely affecting PAF1C function is described.
Journal ArticleDOI
Identification of a superagonist variant of the immunodominant Yellow fever virus epitope NS4b 214-222 by combinatorial peptide library screening.
Amandine Bovay,Vincent Zoete,Pierre J. Rizkallah,Konrad Beck,Philippe Delbreil,Daniel E. Speiser,David K. Cole,Silvia A. Fuertes Marraco +7 more
TL;DR: This LLW-7I superagonist is an example of improved functionality in human CD8 T cells associated with optimized ligand rigidity for TCR binding and not with changes in TCR:pMHC off-rate kinetics.
Journal ArticleDOI
Neoantigen-specific CD8 T cells with high structural avidity preferentially reside in and eliminate tumors
Julien Schmidt,Johanna Chiffelle,Marta A S Perez,Morgane Magnin,Sara Bobisse,Marion Arnaud,Raphael Genolet,J. G. Cesbron,David Barras,Blanca Navarro Rodrigo,Fabrizio Benedetti,Alexandra Michel,Lise Queiroz,Petra Baumgaertner,Philippe Guillaume,Michael Hebeisen,Olivier Michielin,Tu Nguyen-Ngoc,Florian Huber,Melita Irving,S. Tissot-Renaud,Brian Stevenson,Sylvie Rusakiewicz,Denarda Dangaj Laniti,Michal Bassani-Sternberg,Nathalie Rufer,David Gfeller,Lana E. Kandalaft,Daniel E. Speiser,Vincent Zoete,George Coukos,Alexandre Harari +31 more
TL;DR: In this paper , the authors characterize the T cell receptor (TCR) functional (antigen sensitivity) and structural (monomeric pMHC-TCR off-rates) avidities of 371 CD8 T cell clones specific for neoantigens.
Journal ArticleDOI
Structure-based optimization of type III indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors
Ute F. Röhrig,Somi Reddy Majjigapu,Pierre Vogel,Aline Reynaud,Florence Pojer,Nahzli Dilek,Patrick Reichenbach,Kelly Ascencao,Melita Irving,George Coukos,Olivier Michielin,Vincent Zoete +11 more
TL;DR: An extension of the previously described highly efficient haem-binding 1,2,3-triazole and 1, 2,4-Triazole inhibitor series is reported, the best compound having both enzymatic and cellular IC50 values of 34 nM.