V
Vincent Zoete
Researcher at Swiss Institute of Bioinformatics
Publications - 155
Citations - 20005
Vincent Zoete is an academic researcher from Swiss Institute of Bioinformatics. The author has contributed to research in topics: T-cell receptor & T cell. The author has an hindex of 43, co-authored 135 publications receiving 12342 citations. Previous affiliations of Vincent Zoete include Ludwig Institute for Cancer Research & University of Lausanne.
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Journal ArticleDOI
Structure-Function Analyses Point to a Polynucleotide-Accommodating Groove Essential for APOBEC3A Restriction Activities
Yannick Bulliard,Iñigo Narvaiza,Alessandro Bertero,Shyam Peddi,Shyam Peddi,Ute F. Röhrig,Ute F. Röhrig,Millán Ortiz,Vincent Zoete,Nataly Castro-Díaz,Priscilla Turelli,Amalio Telenti,Olivier Michielin,Olivier Michielin,Olivier Michielin,Matthew D. Weitzman,Didier Trono +16 more
TL;DR: A mutational analysis of A3A, examining its ability to restrict LINE-1, AAV-2, and foreign plasmid DNA and to edit a single-stranded DNA substrate, suggests that the target specificity of APOBEC3 family members is partly defined by structural features influencing their interaction with polynucleotide substrates.
Journal ArticleDOI
A comparison of the dynamic behavior of monomeric and dimeric insulin shows structural rearrangements in the active monomer.
TL;DR: The hypothesis that, when monomeric insulin is released from the hexamer (or the dimer in this study), the C-terminal end of the monomer is rearranged to allow binding to the insulin receptor is supported.
Journal ArticleDOI
Double proton transfer in the isolated and DNA-embedded guanine-cytosine base pair
Vincent Zoete,Markus Meuwly +1 more
TL;DR: Differences in the energetics and dynamics of DPT are investigated theoretically for the Watson-Crick conformation of the guanine-cytosine (GC) base pair to address the question of how relevant studies of isolated base pairs are for the understanding of processes occurring in DNA.
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Functional Analysis and Structural Modeling of Human APOBEC3G Reveal the Role of Evolutionarily Conserved Elements in the Inhibition of Human Immunodeficiency Virus Type 1 Infection and Alu Transposition
Yannick Bulliard,Priscilla Turelli,Ute F. Röhrig,Ute F. Röhrig,Vincent Zoete,Bastien Mangeat,Olivier Michielin,Olivier Michielin,Olivier Michielin,Didier Trono +9 more
TL;DR: A large-scale mutagenesis-based analysis of the APOBEC3G N terminus reveals the importance of a predicted RNA binding dimerization interface both for packaging into HIV-1 virions and inhibition of both HIV- 1 infection and Alu transposition.
Journal ArticleDOI
Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors
Ute F. Röhrig,Somi Reddy Majjigapu,Somi Reddy Majjigapu,Marc Chambon,Sylvian Bron,Luc Pilotte,Luc Pilotte,Didier Colau,Didier Colau,Benoît Van den Eynde,Benoît Van den Eynde,Gerardo Turcatti,Pierre Vogel,Vincent Zoete,Olivier Michielin,Olivier Michielin,Olivier Michielin +16 more
TL;DR: A robust and sensitive high-throughput screen for IDO1 inhibitors using the Prestwick Chemical Library of 1200 FDA-approved drugs and the Maybridge HitFinder Collection of 14,000 small molecules is described, which led to more soluble and smaller compounds with micromolar activity.