V
Vincent Zoete
Researcher at Swiss Institute of Bioinformatics
Publications - 155
Citations - 20005
Vincent Zoete is an academic researcher from Swiss Institute of Bioinformatics. The author has contributed to research in topics: T-cell receptor & T cell. The author has an hindex of 43, co-authored 135 publications receiving 12342 citations. Previous affiliations of Vincent Zoete include Ludwig Institute for Cancer Research & University of Lausanne.
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Journal ArticleDOI
Prediction of Cross-Recognition of Peptide-HLA A2 by Melan-A-Specific Cytotoxic T Lymphocytes Using Three-Dimensional Quantitative Structure-Activity Relationships
Theres Fagerberg,Theres Fagerberg,Vincent Zoete,Sebastien Viatte,Petra Baumgaertner,Pedro M. S. Alves,Pedro Romero,Daniel E. Speiser,Olivier Michielin +8 more
TL;DR: Three-dimensional quantitative structure-activity relationships (QSARs) are developed to predict cross-recognition by Melan-A-specific cytotoxic T lymphocytes of peptides bound to HLA A*0201 and suggest that the properties of the unbound epitope are sufficient to capture most of the information to determine the cross- recognition.
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Educational Tools to Introduce Computer-Aided Drug Design to Students and to the Public at Large.
TL;DR: The present article describes what is presently available and the future direction for new activities currently under development in the Drug Design Workshop.
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Electron affinity of tricyclic, bicyclic, and monocyclic compounds containing cyanoenones correlates with their potency as inducers of a cytoprotective enzyme.
René V. Bensasson,Albena T. Dinkova-Kostova,Albena T. Dinkova-Kostova,Suqing Zheng,Akira Saito,Wei Li,Vincent Zoete,Tadashi Honda +7 more
TL;DR: This finding demonstrates that the EA is the essentially important factor that determines the reactivity of the cyanoenones with Keap1, regardless of the molecule size.
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Bi-allelic TTI1 variants cause an autosomal-recessive neurodevelopmental disorder with microcephaly.
Margaux Serey-Gaut,Marisol Cortés,Periklis Makrythanasis,Mohnish Suri,A. Malcolm R. Taylor,Jennifer A. Sullivan,Ayat Asleh,Jaba Mitra,Mohamad Aasif Dar,A. McNamara,Vandana Shashi,Sarah L. Dugan,Xiaofei Song,Jill A. Rosenfeld,Christelle Cabrol,Justyna Iwaszkiewicz,Vincent Zoete,Davut Pehlivan,Zeynep Coban Akdemir,Elizabeth Roeder,Rebecca O. Littlejohn,Harpreet Dibra,Philip J. Byrd,Grant S. Stewart,Bilge Geckinli,Jennifer E. Posey,Rachel Westman,Chelsy R. Jungbluth,Jacqueline Eason,Rani Sachdev,Carey-Anne Evans,Gabrielle Lemire,Grace E. VanNoy,Anne H. O’Donnell-Luria,Frédéric Tran Mau-Them,Aurélien Juven,Juliette Piard,Cheng Yee Nixon,Ying Zhu,Tae Ki Ha,Michael F. Buckley,Christel Thauvin,George K. Essien Umanah,Lionel Van Maldergem,James R. Lupski,Tony Roscioli,Valina L. Dawson,Ted M. Dawson,Stylianos E. Antonarakis +48 more
TL;DR: In this article , the three components of the Triple T (TTT) complex, Telomere maintenance 2 (TELO2), Tel2 interacting protein 2 (TTI2), and Tel 2 interacting protein 1(TTI1), are described in individuals with moderate to severe intellectual disability (ID), short stature, postnatal microcephaly, and a movement disorder.
Journal ArticleDOI
Probing the Conformational Dynamics of Affinity-Enhanced T Cell Receptor Variants upon Binding the Peptide-Bound Major Histocompatibility Complex by Hydrogen/Deuterium Exchange Mass Spectrometry.
Patrick S. Merkle,Esben Trabjerg,Song Hongjian,Mathias Ferber,Michel A. Cuendet,Michel A. Cuendet,Thomas J. D. Jørgensen,Immanuel F. Luescher,Melita Irving,Melita Irving,Vincent Zoete,Olivier Michielin,Kasper D. Rand +12 more
TL;DR: In this paper, the authors conducted hydrogen/deuterium exchange mass spectrometry (HDX-MS) analyses of individual affinity-enhanced TCR variants and clinically relevant pMHC class I molecules (HLA-A*0201/NY-ESO-1157-165) to investigate the causality between increased binding affinity and conformational dynamics in TCR-pMHC complexes.