V
Vincent Zoete
Researcher at Swiss Institute of Bioinformatics
Publications - 155
Citations - 20005
Vincent Zoete is an academic researcher from Swiss Institute of Bioinformatics. The author has contributed to research in topics: T-cell receptor & T cell. The author has an hindex of 43, co-authored 135 publications receiving 12342 citations. Previous affiliations of Vincent Zoete include Ludwig Institute for Cancer Research & University of Lausanne.
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Journal ArticleDOI
Inhibition Mechanisms of Indoleamine 2,3-Dioxygenase 1 (IDO1)
Ute F. Röhrig,Aline Reynaud,Somi Reddy Majjigapu,Somi Reddy Majjigapu,Pierre Vogel,Florence Pojer,Vincent Zoete,Vincent Zoete +7 more
TL;DR: A classification scheme for IDO1 inhibitors according to their inhibition mechanism is proposed, which will be useful for further developments in the field and based on a comprehensive literature overview is proposed.
Journal ArticleDOI
The Peroxisomal Enzyme L-PBE Is Required to Prevent the Dietary Toxicity of Medium-Chain Fatty Acids.
Jun B Ding,Ursula Loizides-Mangold,Gianpaolo Rando,Vincent Zoete,Olivier Michielin,Janardan K. Reddy,Walter Wahli,Walter Wahli,Howard Riezman,Bernard Thorens +9 more
TL;DR: The correct homeostasis of dicarboxylic fatty acids is a means to regulate the efficient utilization of ingested medium-chain fatty acids, and its deregulation exemplifies the intricate relationship between impaired metabolism and inflammation.
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How T cell receptors interact with peptide-MHCs: a multiple steered molecular dynamics study.
TL;DR: This study performs extensive equilibrium and steered molecular dynamics simulations to study the unbinding of three TCR‐pMHC complexes and illustrates how two TCRs with similar reactivity and structures can have essentially different binding strategies.
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Distinct sets of αβ TCRs confer similar recognition of tumor antigen NY-ESO-1157-165 by interacting with its central Met/Trp residues
Laurent Derré,Marc Bruyninx,Petra Baumgaertner,Mathias Ferber,Daphné Schmid,Antoine Leimgruber,Vincent Zoete,Pedro Romero,Olivier Michielin,Daniel E. Speiser,Nathalie Rufer +10 more
TL;DR: This in-depth study of recognition of a self-antigen suggests that in part similar biophysical mechanisms shape TCR repertoires toward foreign andSelf-antigens.
Journal ArticleDOI
Pharmacological disruption of the Notch transcription factor complex.
Rajwinder Lehal,Jelena Zaric,Michele Vigolo,Charlotte Urech,Viktoras Frismantas,Nadine Zangger,Linlin Cao,Adeline Berger,Irene Chicote,Sylvain Loubéry,Sung Hee Choi,Ute Koch,Stephen C. Blacklow,Hector G. Palmer,Beat Bornhauser,Marcos González-Gaitán,Yvan Arsenijevic,Vincent Zoete,Vincent Zoete,Jon C. Aster,Jean-Pierre Bourquin,Freddy Radtke +21 more
TL;DR: A pharmacological strategy that interferes with Notch signaling by disrupting the Notch transcription complex and shows therapeutic potential for treating Notch-driven cancers is described.