V
Vincent Zoete
Researcher at Swiss Institute of Bioinformatics
Publications - 155
Citations - 20005
Vincent Zoete is an academic researcher from Swiss Institute of Bioinformatics. The author has contributed to research in topics: T-cell receptor & T cell. The author has an hindex of 43, co-authored 135 publications receiving 12342 citations. Previous affiliations of Vincent Zoete include Ludwig Institute for Cancer Research & University of Lausanne.
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Journal ArticleDOI
The caveolin-binding motif of the pathogen-related yeast protein Pry1, a member of the CAP protein superfamily, is required for in vivo export of cholesteryl acetate.
Vineet Choudhary,Rabih Darwiche,David Gfeller,Vincent Zoete,Olivier Michielin,Roger Schneiter +5 more
TL;DR: Analysis of the mode of sterol binding by Pry1 indicates that the caveolin-binding motif of Pry1, and possibly of other CAP family members, is crucial for selective lipid binding and that lipid binding may occur through displacement of the loop containing this motif.
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FGFR2 Extracellular Domain In-Frame Deletions Are Therapeutically Targetable Genomic Alterations That Function as Oncogenic Drivers in Cholangiocarcinoma.
James M. Cleary,Srivatsan Raghavan,Qibiao Wu,Yvonne Y. Li,Liam F. Spurr,Hersh Gupta,Douglas A. Rubinson,Isobel J Fetter,Jason L. Hornick,Jonathan A. Nowak,Giulia Siravegna,Lipika Goyal,Lei Shi,Lauren K. Brais,Maureen Loftus,Atul B. Shinagare,Thomas A. Abrams,Thomas E. Clancy,Jiping Wang,Anuj K. Patel,Franck Brichory,Anne Vaslin Chessex,Ryan J. Sullivan,Rachel B. Keller,Sarah L. Denning,Emma R. Hill,Geoffrey I. Shapiro,Anna Pokorska-Bocci,Claudio Zanna,Kimmie Ng,Deborah Schrag,Pasi A. Jänne,William C. Hahn,Andrew D. Cherniack,Ryan B. Corcoran,Matthew Meyerson,Antoine Daina,Vincent Zoete,Nabeel Bardeesy,Brian M. Wolpin +39 more
TL;DR: FGFR2 EIDs are revealed as an alternative mechanism of FGFR2 activation in IHCC that predict sensitivity to FGFR inhibitors in the clinic and reveal the genomic landscape by anatomic site within the biliary tree.
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1,2,3-Triazoles as inhibitors of indoleamine 2,3-dioxygenase 2 (IDO2).
Ute F. Röhrig,Somi Reddy Majjigapu,Daniela Caldelari,Nahzli Dilek,Patrick Reichenbach,Kelly Ascencao,Melita Irving,George Coukos,George Coukos,Pierre Vogel,Pierre Vogel,Vincent Zoete,Olivier Michielin,Olivier Michielin +13 more
TL;DR: This work used computational structure-based methods to design inhibitors of IDO2 which were then tested in cellular assays and yielded low molecular weight inhibitors, the most active displaying an IC50 value of 51μM for mIDO2, and twofold selectivity over hIDO1.
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The SwissSimilarity 2021 Web Tool: Novel Chemical Libraries and Additional Methods for an Enhanced Ligand-Based Virtual Screening Experience
TL;DR: The new version of SwissSimilarity web tool features additional 2D and 3D methods for estimation of molecular similarity: extended-connectivity, MinHash, 2D pharmacophore, extended reduced graph, and extended 3D fingerprints, and it is now possible to screen for molecular structures having the same scaffold as the query compound.
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Unique Spectrum of Activity of Prosimian TRIM5α against Exogenous and Endogenous Retroviruses
Nadia Rahm,Melvyn W. Yap,Joke Snoeck,Joke Snoeck,Vincent Zoete,Miguel Munoz,Ute Radespiel,Elke Zimmermann,Olivier Michielin,Jonathan P. Stoye,Angela Ciuffi,Amalio Telenti +11 more
TL;DR: The activities of TRIM5α proteins from two distant lemurs against exogenous retroviruses and a chimeric PSIV are characterized and the prediction of ancestral simian sequences hint at an evolutionary scenario where antiretroviral specificity is prominently defined by the lineage-specific expansion of the variable loops of B30.2/SPRY.