Vincent Zoete

TL;DR: The mechanisms regulating exhaustion of tumor-infiltrating lymphocytes (TIL) and responsiveness to PD-1 blockade remain partly unknown in human ovarian cancer, and as mentioned in this paper showed that tumor-specific CD8+ TIL accumulate in tumor islets, where they engage antigen and upregulate PD1, which restrains their functions.

TL;DR: It is established that changes in formin nucleation and elongation rates have direct consequences on the architecture of the fusion focus, and that Fus1 native high nucleations and low elongations rates are optimal for fusion focus assembly.

TL;DR: Le taux moyen de mutations pour les BCC etait de 65/Mb, soit le chiffre le plus eleve de tous les cancers humains, while l’ADN controle etait obtenu sur sang peripherique dans 90 % des cas.

TL;DR: In this article , the authors identify 18 likely pathogenic variants in 21 probands (3.1%) in FOXI3 and provide suggestive evidence that common variation in the FoxI3 allele in trans with the pathogenic variant could modify the phenotypic severity and accounts for the incomplete penetrance.

TL;DR: In this article, the present invention relates to methods of designing kinase mutants for reprogramming the sensitivity of a target kinase to some specific inhibitors, wherein those kinase inhibitors have little or no affinity for the wild-type target Kinase, vectors or cells expressing said mutated kinases, composition and uses thereof for the prevention and/or treatment of a disease or disorder, in particular cancer.