S
Shraddha Pai
Researcher at University of Toronto
Publications - 26
Citations - 1153
Shraddha Pai is an academic researcher from University of Toronto. The author has contributed to research in topics: Gene & Medicine. The author has an hindex of 12, co-authored 20 publications receiving 921 citations. Previous affiliations of Shraddha Pai include Watson School of Biological Sciences & Ontario Institute for Cancer Research.
Papers
More filters
Journal ArticleDOI
5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary.
Tarang Khare,Shraddha Pai,Karolis Koncevičius,Karolis Koncevičius,Mrinal Pal,Edita Kriukiene,Zita Liutkeviciute,Manuel Irimia,Peixin Jia,Carolyn Ptak,Menghang Xia,Raymond R. Tice,Mamoru Tochigi,Solange Moréra,Anaies Nazarians,Denise D. Belsham,Albert H.C. Wong,Benjamin J. Blencowe,Sun Chong Wang,Sun Chong Wang,Philipp Kapranov,Rafal Kustra,Viviane Labrie,Saulius Klimašauskas,Arturas Petronis +24 more
TL;DR: A new role for 5-hmC in RNA splicing and synaptic function in the brain is suggested as well as substantial tissue-specific differential distributions of these DNA modifications at the exon-intron boundary in human and mouse tissues.
Journal ArticleDOI
WormBase: a comprehensive data resource for Caenorhabditis biology and genomics
Nansheng Chen,Todd W. Harris,Igor Antoshechkin,Carol Bastiani,Tamberlyn Bieri,Darin Blasiar,Keith Bradnam,Payan Canaran,Juancarlos Chan,Chao-Kung Chen,Wen J. Chen,Fiona Cunningham,Paul H. Davis,Eimear E. Kenny,Ranjana Kishore,Daniel Lawson,Raymond Lee,Hans-Michael Müller,Cecilia Nakamura,Shraddha Pai,Philip Ozersky,Andrei Petcherski,Anthony Rogers,Aniko Sabo,Erich M. Schwarz,Kimberly Van Auken,Qinghua Wang,Richard Durbin,John Spieth,Paul W. Sternberg,Lincoln Stein +30 more
TL;DR: Internally, the database models are restructured to rationalize the representation of genes and to prepare the system to accept the genome sequences of three additional Caenorhabditis species over the coming year.
Journal ArticleDOI
A multi-tissue analysis identifies HLA complex group 9 gene methylation differences in bipolar disorder.
Zachary Kaminsky,M. Tochigi,M. Tochigi,P. Jia,Mrinal Pal,Jonathan Mill,Jonathan Mill,Andrew Kwan,Ilya Ioshikhes,John B. Vincent,James L. Kennedy,John Strauss,Shraddha Pai,Sun Chong Wang,Sun Chong Wang,Arturas Petronis +15 more
TL;DR: The consistent multi-tissue epigenetic differences at HCG9 argue for a causal association with BPD.
Journal ArticleDOI
Epigenetics of major psychosis: progress, problems and perspectives
TL;DR: Recent epigenetic studies examining the brain and other tissues, including those from individuals with schizophrenia (SCZ) and bipolar disorder (BPD), are reviewed and the future directions of psychiatric epigenetics are discussed.
Journal ArticleDOI
Patient Similarity Networks for Precision Medicine.
Shraddha Pai,Gary D. Bader +1 more
TL;DR: This work reviews new methods based on patient similarity networks, including Similarity Network Fusion for patient clustering and netDx for patient classification, and assesses the utility of network-based algorithms for precision medicine.