Dante S. Bortone

TL;DR: An extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA identifies six immune subtypes that encompass multiple cancer types and are hypothesized to define immune response patterns impacting prognosis.

TL;DR: This study establishes layer six in the primary visual cortex of the mouse as a major mediator of cortical gain modulation and suggests that it could be a node through which convergent inputs from several brain areas can regulate the earliest steps of cortical visual processing.

TL;DR: It is demonstrated that the bHLH transcription factor Neurogenin2 (Ngn2) is both necessary and sufficient for specifying the dendritic morphology of pyramidal neurons in vivo by specifying the polarity of its leading process during the initiation of radial migration.

TL;DR: It is demonstrated that, prior to synaptogenesis, migrating interneurons change their responsiveness to ambient GABA from a motogenic to a stop signal, which suggests a mechanism whereby migrating interneeurons determine the relative density of surrounding interneuronons and principal cells through their ability to sense the combined extracellular levels of ambient glutamate and GABA once GABA(A) receptor activation becomes hyperpolarizing.

TL;DR: A circuit by which L6 modulates cortical activity is revealed and an inhibitory neuron able to regulate the strength of cortical responses throughout cortical depth is identified.