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Walter J. Bruyninckx
Researcher at Hanover College
Publications - 12
Citations - 748
Walter J. Bruyninckx is an academic researcher from Hanover College. The author has contributed to research in topics: Colitis & Phagocytosis. The author has an hindex of 8, co-authored 12 publications receiving 653 citations. Previous affiliations of Walter J. Bruyninckx include Brigham and Women's Hospital & Colorado State University.
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Journal ArticleDOI
Transmigrating Neutrophils Shape the Mucosal Microenvironment through Localized Oxygen Depletion to Influence Resolution of Inflammation
Eric L. Campbell,Walter J. Bruyninckx,Caleb J. Kelly,Louise E. Glover,Eóin N. McNamee,Brittelle E. Bowers,Amanda J. Bayless,Melanie Scully,Bejan Saeedi,Lucy Golden-Mason,Stefan F. Ehrentraut,Valerie F. Curtis,Adrianne Burgess,John F. Garvey,Amber Sorensen,Raphael A. Nemenoff,Paul Jedlicka,Cormac T. Taylor,Douglas J. Kominsky,Sean P. Colgan +19 more
TL;DR: In this paper, the authors investigated the contribution of neutrophils and respiratory burst to inflammatory hypoxia and effective inflammatory resolution in a colitis model using HIF-inducible factor (HIF) mice.
Journal ArticleDOI
Resolvin E1-induced intestinal alkaline phosphatase promotes resolution of inflammation through LPS detoxification
Eric L. Campbell,Christopher F. MacManus,Douglas J. Kominsky,Simon Keely,Louise E. Glover,Brittelle E. Bowers,M Scully,Walter J. Bruyninckx,Sean P. Colgan +8 more
TL;DR: Administration of RvE1 resulted in significant improvement of disease activity indices concomitant with increased ALPI expression in the intestinal epithelium, and inhibition of ALPI activity resulted in increased severity of colitis in DSS-treated animals and partially abrogated the protective influence of R vE1.
Journal ArticleDOI
Antiadhesive Role of Apical Decay-accelerating Factor (CD55) in Human Neutrophil Transmigration across Mucosal Epithelia
Donald W. Lawrence,Walter J. Bruyninckx,Walter J. Bruyninckx,Nancy A. Louis,Douglas M. Lublin,Gregory L. Stahl,Charles A. Parkos,Sean P. Colgan +7 more
TL;DR: The elucidation of DAF as an apical epithelial ligand for PMN provides a target for novel anti-inflammatory therapies directed at quelling unwanted inflammatory episodes.
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Phosphoinositide 3-kinase modulation of β3-integrin represents an endogenous “braking” mechanism during neutrophil transmatrix migration
TL;DR: Data indicate that PI3K-regulated beta(3)-integrin represents a natural "braking" mechanism for PMNs during transit through the extracellular matrix.
Journal Article
Neutrophil function in normal and Chediak-Higashi syndrome cats following administration of recombinant canine granulocyte colony-stimulating factor.
Sean P. Colgan,Peter W. Gasper,Mary Anna Thrall,T. C. Boone,Anne-Marie B. Blancquaert,Walter J. Bruyninckx +5 more
TL;DR: It is concluded that neutrophils elicited by rcG-CSF are functionally enhanced and thatrcG- CSF may be a viable therapy for CHS and other related disorders.