다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

[신간의 별자리x] 우리/미술, 그리고 ‘슬픔의 박물관’

CA : A Cancer Journal for Clinicians

On September 14, 2015 at 09:50:45 UTC the two detectors of the Laser Interferometer Gravitational-Wave Observatory simultaneously observed a transient gravitational-wave signal. The signal sweeps upwards in frequency from 35 to 250 Hz with a peak gravitational-wave strain of 1.0×10(-21). It matches the waveform predicted by general relativity for the inspiral and merger of a pair of black holes and the ringdown of the resulting single black hole. The signal was observed with a matched-filter signal-to-noise ratio of 24 and a false alarm rate estimated to be less than 1 event per 203,000 years, equivalent to a significance greater than 5.1σ. The source lies at a luminosity distance of 410(-180)(+160)  Mpc corresponding to a redshift z=0.09(-0.04)(+0.03). In the source frame, the initial black hole masses are 36(-4)(+5)M⊙ and 29(-4)(+4)M⊙, and the final black hole mass is 62(-4)(+4)M⊙, with 3.0(-0.5)(+0.5)M⊙c(2) radiated in gravitational waves. All uncertainties define 90% credible intervals. These observations demonstrate the existence of binary stellar-mass black hole systems. This is the first direct detection of gravitational waves and the first observation of a binary black hole merger.

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The Observation of Gravitational Waves from a Binary Black Hole Merger

Monte Carlo simulation of miscibility of polymer blends with repulsive interactions: effect of chain structure

In this paper, we study the self-assembly of diblock copolymers under shear flow by combining the self-consistent field (SCF) and lattice Boltzmann (LB) method. We perform LB and SCF simulations in the same lattice, and set SCF simulation results as the input of LB, and then feedback the LB results to SCF simulation. This process is repeated until the system reaches an equilibrium state. This combined simulation method has the advantages of both LB and SCF simulations. It can thus be used to study the self-assembly of a defined copolymer in a real shear flow field. The simulative results imply that the self-assembled morphology of diblock copolymers under shear flow depends on the shear rate and shear frequency. The results correlate well with the experiment.

Self-assembly of diblock copolymers under shear flow: A simulation study by combining the self-consistent field and lattice Boltzmann method

Sa1701 Cytotoxic T Lymphocyte Antigen-4 (Ctla-4) Signaling Effectively Retains Regulatory T Cells (Treg) to Alleviate Liver Injury of Patients With Acute-on-Chronic Hepatitis B (Achb)

Ring- and rod-shaped P4VP-b-PS-b-P4VP (PS, polystyrene; P4VP, poly(4-vinylpyridine)) triblock copolymer aggregates are used as templates to synthesize ZnS nanocrystals. Herein, PVP serves as both a stabilizing agent and a structure-directing agent. The resulting ZnS nanocrystals could be aligned along the corona of the copolymer aggregates in near-perfect structures through control of both the molar ratio of Zn2+ to P4VP and the reaction time. The diameter of the as-synthesized ZnS layer on the surface of polymer template is approximate 2–3 nm. High-resolution transmission electron microscopy images reveal that the ZnS particles are single crystal in a zinc blende structure. This method provides a simple, reproducible route at room temperature to prepare assembled hybrid polymer–semiconductor nanocrystal nanocomposites.

Well-organized structures of ZnS semiconductor nanocrystals using amphiphilic triblock copolymer aggregates as templates

DNA-functionalized gold nanoparticles (DNA–AuNPs) have shown great potential and exciting opportunities for constructing machine-like nanodevices. Nonthiolated DNA can be grafted onto gold surfaces via DNA bases, such as polyadenine (polyA)–DNA. The colloidal stability of polyA–DNA–AuNPs has a significant dependency on salt and pH that affects the assembly of AuNPs and their application in polyA–DNA molecular machines. High salt and low pH value contribute to the stabilization of polyA–DNA–AuNPs. In acid conditions, adenine can be protonated and becomes positively-charged, thus enhancing the adsorption of polyA–DNA onto the gold surface by electrostatic interactions; coordination of multiple interactions achieves a high DNA grafting density and colloidal stability. In addition, the length of adenine has an important effect on the efficiency of the DNA machine, while the length of thymine has little effect when the thymine length is less than or equal to seven. The assembly of AuNPs driven by dynamic polyA–DNA molecular machines was successfully accomplished with A5-DNA and A9-DNA. A moderate concentration of catalyst oligomer (50 nM) could improve the DNA hybridization efficiency. The A9-DNA based molecular machine is more efficient than the A5-DNA based one because of the larger amount of A9-DNA on the AuNPs, which increases the probability of collisions between complementary DNA strands. Therefore, polyA–DNA functionalized nanoparticles can be used as a basic unit to construct assembly-ordering structures and achieve dynamic molecular machines to be applied in the molecular diagnostics field.

Wei Jiang

Papers

Monte Carlo simulation of miscibility of polymer blends with repulsive interactions: effect of chain structure

Self-assembly of diblock copolymers under shear flow: A simulation study by combining the self-consistent field and lattice Boltzmann method

Sa1701 Cytotoxic T Lymphocyte Antigen-4 (Ctla-4) Signaling Effectively Retains Regulatory T Cells (Treg) to Alleviate Liver Injury of Patients With Acute-on-Chronic Hepatitis B (Achb)

Well-organized structures of ZnS semiconductor nanocrystals using amphiphilic triblock copolymer aggregates as templates

Enhancing the stability of single-stranded DNA on gold nanoparticles as molecular machines through salt and acid regulation.