다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

[신간의 별자리x] 우리/미술, 그리고 ‘슬픔의 박물관’

CA : A Cancer Journal for Clinicians

On September 14, 2015 at 09:50:45 UTC the two detectors of the Laser Interferometer Gravitational-Wave Observatory simultaneously observed a transient gravitational-wave signal. The signal sweeps upwards in frequency from 35 to 250 Hz with a peak gravitational-wave strain of 1.0×10(-21). It matches the waveform predicted by general relativity for the inspiral and merger of a pair of black holes and the ringdown of the resulting single black hole. The signal was observed with a matched-filter signal-to-noise ratio of 24 and a false alarm rate estimated to be less than 1 event per 203,000 years, equivalent to a significance greater than 5.1σ. The source lies at a luminosity distance of 410(-180)(+160)  Mpc corresponding to a redshift z=0.09(-0.04)(+0.03). In the source frame, the initial black hole masses are 36(-4)(+5)M⊙ and 29(-4)(+4)M⊙, and the final black hole mass is 62(-4)(+4)M⊙, with 3.0(-0.5)(+0.5)M⊙c(2) radiated in gravitational waves. All uncertainties define 90% credible intervals. These observations demonstrate the existence of binary stellar-mass black hole systems. This is the first direct detection of gravitational waves and the first observation of a binary black hole merger.

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The Observation of Gravitational Waves from a Binary Black Hole Merger

The invention relates to a lower tube base buoyancy locking mechanism of a lead-based reactor fuel component. The mechanism comprises a reactor core grid plate, a lower tube base, a floating sliding cylinder and ball anchors, wherein a through pore is formed in the reactor core grid plate; a plurality of locking grooves are formed in the inner wall of the pore along a circumferential direction; the lower tube base is positioned and inserted into the pore of the reactor core grid plate; a plurality of ball anchor holes are formed in the lower tube base along a circumferential direction in an area of the lower tube base inserted into the reactor core grid plate; the floating sliding cylinder is coaxially arranged inside the lower tube base and can make vertical axial movement along with buoyancy; a plurality sections of chutes are formed in the outer wall surface of the lower part of the floating sliding cylinder; and a plurality of ball anchors are respectively limited between the ballanchor holes in the lower tube base and the plurality sections of chutes in the floating sliding cylinder and can only make horizontal axial movement along the ball anchor holes in the lower tube base. According to the mechanism, the ball anchors are externally pushed and clamped into the locking grooves of the reactor core grid plate through a lower tube base through hole through buoyancy under push of the plurality sections of chutes of the floating sliding cylinder, so that the ball anchors are positioned among the reactor core grid plate, the lower tube base and the floating sliding cylinder in a stop pin mode, and mutual movement of the three components can be limited.

Lower tube base buoyancy locking mechanism of lead-based reactor fuel component

OBJECTIVES
To explore the effects of kinesiotaping in the treatment of shoulder pain and upper limb function in stroke survivors.


METHODS
PubMed, EMBASE and the Cochrane Central Register of Controlled Trials were electronically and manually searched to identify relevant publications from inception to March 1, 2022. Full-text qualitative studies that explored the effects of kinesiotaping on hemiplegic shoulder pain and poststroke upper limb spasticity were included in the analysis. Data synthesis with a thematic approach was performed to generate descriptive and analytical themes.


RESULTS
Nine randomized controlled trials with 253 participants were included. The meta-analysis showed that kinesiotaping significantly reduced poststroke shoulder pain (mean difference (MD) = -1.59, 95% confidence interval (CI): -3.21 to -0.02, P = 0.05), enhanced range of motion (ROM) (MD = 7.00, 95% CI: 2.3 to 11.7, P = 0.004), reduced Modified Ashworth scale (MAS) scores (MD = -0.26, 95% CI: -0.51 to -0.01, P = 0.04), and decreased the magnitude of shoulder subluxation (MD = -0.42, 95% CI: -0.76 to -0.08, P = 0.02). However, outcomes, such as the Fugl-Meyer score and Barthel index, did not differ between the kinesiotaping and control groups.


CONCLUSIONS
Kinesiotaping effectively relieved shoulder pain, improved upper limb spasticity and ROM, and reduced shoulder subluxation in stroke survivors. However, the effects of kinesiotaping on upper limb function in terms of FMA-UE scores and independence in activities of daily living were not verified. High-quality RCTs designed with large sample sizes are still required in the future.

Effect of kinesiotaping on pain relief and upper limb function in stroke survivors: a systematic review and meta-analysis.

The microphase separation behavior of linear ABC triblock copolymers in A-selective solvents are studied using Monte Carlo simulation. The ABC triblock copolymer used in this study has a short solvophilic block A and two long solvophobic blocks B and C. The effects of the solvophobicity difference and the incompatibility between solvophobic blocks B and C on the micelle morphologies formed by linear ABC triblock copolymers are investigated, and phase diagrams as a function of the solvophobicity of blocks B and C are given at different repulsions between blocks B and C, respectively. A series of multicompartment micelles with distinct solvophobic parts is obtained, such as pupa-like multi-layered micelles, hamburger-like micelles and bumpy disks. Remarkably, when the solvophobicity of blocks B is much stronger than that of blocks C, a novel reverse core–shell–corona micelle with solvophilic blocks A located in the center of the micelle is obtained. Moreover, the results indicate that the competition between the effects of the incompatibility and solvophobicity difference between blocks B and C determines the microphase separation structures in the multicompartment micelles. These simulation results elucidate the mechanism of the formation of ABC triblock copolymer nanostructures and provide theoretical guidance for experimental studies.

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Effect of solvophobicity on the phase behavior of linear ABC triblock copolymers in selective solvents: a Monte Carlo study

The cloud-point temperatures (T-cl's) of both binary poly(ethylene oxide) (PEO)-poly(ethylene oxide-b-dimethylsiloxane) [P(EO-b-DMS)] and ternary[toluene/PEO/P(EO-b-DMS)] systems were determined by light scattering measurements at atmospheric pressure. The phase separation behavior upon cooling in the ternary system has been investigated at atmospheric pressure and under high pressure and compared to the phase behavior in the binary system. The phase transition temperatures have been obtained for all of the samples. As a result, the pressure induces compatibility in the binary mixtures, but for the ternary system, pressure not only can induce mixing but also can induce phase separation.

Abnormal pressure dependence of the phase boundaries in TL/PEO/P(EO-b-DMS) ternary mixtures

The invention relates to an upper tube base self-locking mechanism of a lead-based reactor fuel component and is used to cooperate with a lower tube base buoyancy locking mechanism and a refueling grasping mechanism to work. The upper tube base self-locking mechanism comprises an upper tube base, self-locking hook claw boxes and hook claw rings, wherein a plurality of self-locking hook claw boxesare arranged in the upper tube base; and the hook claw rings are arranged inside the upper tube base in a sliding manner, are connected with upper ends of push rods of the lower tube base buoyancy locking mechanism and are matched with the self-locking hook claw boxes to achieve self locking. Through the self-locking hook claw boxes with a self-locking function, the hook claw rings are constrainedby self-locking hook claws to move downwards, then a floating sliding cylinder of the lower tube base buoyancy locking mechanism is limited from moving downwards, the position of the floating slidingcylinder can be fixed, a constraint state of a ball anchor can be maintained, the ball anchor is not unlocked under a working condition of earthquake, the upper tube base self-locking mechanism is safety guarantee of buoyancy locking of the ball anchor, and the problem that a fuel component is unlocked as a buoyancy locking device floats up under an earthquake load can be effectively avoided.

Wei Jiang

Papers

Lower tube base buoyancy locking mechanism of lead-based reactor fuel component

Effect of kinesiotaping on pain relief and upper limb function in stroke survivors: a systematic review and meta-analysis.

Effect of solvophobicity on the phase behavior of linear ABC triblock copolymers in selective solvents: a Monte Carlo study

Abnormal pressure dependence of the phase boundaries in TL/PEO/P(EO-b-DMS) ternary mixtures

Upper tube base self-locking mechanism of lead-based reactor fuel component