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Weiguang Luo
Researcher at Central South University
Publications - 6
Citations - 167
Weiguang Luo is an academic researcher from Central South University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 3, co-authored 3 publications receiving 94 citations. Previous affiliations of Weiguang Luo include University of Texas Southwestern Medical Center.
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Journal ArticleDOI
LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration
Mi Deng,Xun Gui,Jaehyup Kim,Li Xie,Weina Chen,Zunling Li,Zunling Li,Licai He,Licai He,Yuanzhi Chen,Yuanzhi Chen,Heyu Chen,Weiguang Luo,Weiguang Luo,Zhigang Lu,Zhigang Lu,Jingjing Xie,Jingjing Xie,Hywyn Churchill,Yixiang Xu,Zhan Zhou,Guojin Wu,Chenyi Yu,Chenyi Yu,Samuel John,Kouyuki Hirayasu,Nam X. Nguyen,Xiaoye Liu,Fangfang Huang,Fangfang Huang,Leike Li,Hui Deng,Haidong Tang,Ali H. Sadek,Lingbo Zhang,Lingbo Zhang,Tao Huang,Yizhou Zou,Benjamin P C Chen,Hong Zhu,Hisashi Arase,Ningshao Xia,Youxing Jiang,Robert H. Collins,M. James You,Jade Homsi,Nisha Unni,Cheryl M. Lewis,Guo-Qiang Chen,Yang Xin Fu,X. Charlene Liao,Zhiqiang An,Junke Zheng,Ningyan Zhang,Cheng Cheng Zhang +54 more
TL;DR: It is shown that LILRB4, an immunoreceptor tyrosine-based inhibition motif-containing receptor and a marker of monocytic leukaemia, supports tumour cell infiltration into tissues and suppresses T cell activity via a signalling pathway that involves APOE, LIL RB4, SHP-2, uPAR and ARG1 in acute myeloid leukaemis (AML) cells.
Journal ArticleDOI
Tumor-Derived Soluble MICA Obstructs the NKG2D Pathway to Restrain NK Cytotoxicity
Qizhi Luo,Weiguang Luo,Weiguang Luo,Quan Zhu,Hongjun Huang,Huiyun Peng,Rongjiao Liu,Min Xie,Shili Li,Ming Li,Xiaocui Hu,Yizhou Zou +11 more
TL;DR: SMICA obstructs the activation of NKG2D pathway to protect tumor cells from NK cell-mediated cytotoxicity and the number of GFP-expressing cells decreased sharply in presence of sMICA.
Journal ArticleDOI
NK cell-mediated anti-leukemia cytotoxicity is enhanced using a NKG2D ligand MICA and anti-CD20 scfv chimeric protein
Yizhou Zou,Weiguang Luo,Weiguang Luo,Jing Guo,Qizhi Luo,Mi Deng,Zhigang Lu,Yi Fang,Cheng Cheng Zhang +8 more
TL;DR: A fusion protein consisting of the extracellular domain of the NKG2D ligand MICA and the anti‐CD20 single‐chain variable fragment is produced, capable of binding both NK cells and CD20+ tumor cells.
Journal ArticleDOI
A Soluble NK-CAR Mediates the Specific Cytotoxicity of NK Cells toward the Target CD20+ Lymphoma Cells
Rongjiao Liu,Qizhi Luo,Weiguang Luo,Ling Wan,Quan Zhu,Xiangli Yin,Xiaofang Lu,Zixuan Song,Leiyan Wei,Zhiqing Xiang,Yizhou Zou +10 more
TL;DR: The soluble NK-CAR mediated the NKL cell killing of CD20+ Daudi cells in vitro, with a 1 µg/mL concentration inducing the maximum killing effect, highlighting the clinical application potential of this novel immunotherapy for killing target tumor cells.
Journal ArticleDOI
Proteome-wide analysis of lysine β-hydroxybutyrylation in the myocardium of diabetic rat model with cardiomyopathy
TL;DR: In this article , the authors quantitatively analyzed the kbhb residues on heart tissues of a diabetic cardiomyopathy (DCM) model rat, using affinity enrichment and liquid chromatography-mass spectrometry (LC-MS/MS) method.