Y
Yixiang Xu
Researcher at Baylor College of Medicine
Publications - 22
Citations - 819
Yixiang Xu is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Metastasis & Breast cancer. The author has an hindex of 15, co-authored 21 publications receiving 619 citations. Previous affiliations of Yixiang Xu include Texas A&M University & University of Texas Health Science Center at Houston.
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Journal ArticleDOI
LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration
Mi Deng,Xun Gui,Jaehyup Kim,Li Xie,Weina Chen,Zunling Li,Zunling Li,Licai He,Licai He,Yuanzhi Chen,Yuanzhi Chen,Heyu Chen,Weiguang Luo,Weiguang Luo,Zhigang Lu,Zhigang Lu,Jingjing Xie,Jingjing Xie,Hywyn Churchill,Yixiang Xu,Zhan Zhou,Guojin Wu,Chenyi Yu,Chenyi Yu,Samuel John,Kouyuki Hirayasu,Nam X. Nguyen,Xiaoye Liu,Fangfang Huang,Fangfang Huang,Leike Li,Hui Deng,Haidong Tang,Ali H. Sadek,Lingbo Zhang,Lingbo Zhang,Tao Huang,Yizhou Zou,Benjamin P C Chen,Hong Zhu,Hisashi Arase,Ningshao Xia,Youxing Jiang,Robert H. Collins,M. James You,Jade Homsi,Nisha Unni,Cheryl M. Lewis,Guo-Qiang Chen,Yang Xin Fu,X. Charlene Liao,Zhiqiang An,Junke Zheng,Ningyan Zhang,Cheng Cheng Zhang +54 more
TL;DR: It is shown that LILRB4, an immunoreceptor tyrosine-based inhibition motif-containing receptor and a marker of monocytic leukaemia, supports tumour cell infiltration into tissues and suppresses T cell activity via a signalling pathway that involves APOE, LIL RB4, SHP-2, uPAR and ARG1 in acute myeloid leukaemis (AML) cells.
Journal ArticleDOI
Twist1 promotes breast cancer invasion and metastasis by silencing Foxa1 expression
TL;DR: It is demonstrated that Twist1’s silencing effect on Foxa1 expression is largelyresponsible for Twist1-induced migration, invasion and metastasis, but less responsible for Twist2-induced mesenchymal morphogenesis and expression of certain EMT markers.
Journal ArticleDOI
Breast tumor cell-specific knockout of Twist1 inhibits cancer cell plasticity, dissemination, and lung metastasis in mice.
Yixiang Xu,Yixiang Xu,Dong-Kee Lee,Zhen Feng,Yan Xu,Yan Xu,Wen Bu,Yi Li,Lan Liao,Jianming Xu +9 more
TL;DR: It is found that Twist1 is coexpressed with multiple other epithelial–mesenchymal transition (EMT)-inducing transcription factors (TFs) in small subsets of primary and circulating breast tumor cells, which most likely are responsible for disseminating into the circulation and metastasizing to the lung in mice.
Journal ArticleDOI
Autophagy mediates HIF2α degradation and suppresses renal tumorigenesis.
Xian De Liu,Jun Yao,Durga Nand Tripathi,Zhiyong Ding,Yixiang Xu,Mianen Sun,Jiangwei Zhang,Shanshan Bai,Peter German,Anh Hoang,Lijun Zhou,D. Jonasch,X. Zhang,Claudio J. Conti,Eleni Efstathiou,Nizar M. Tannir,N. T. Eissa,Gordon B. Mills,Cheryl L. Walker,Eric Jonasch +19 more
TL;DR: This study indicates that autophagy has an anticancer role in ccRCC tumorigenesis, and suggests that constitutive autophagic degradation of HIF2α is a novel tumor suppression mechanism.
Journal ArticleDOI
Overexpression of transcriptional coactivator AIB1 promotes hepatocellular carcinoma progression by enhancing cell proliferation and invasiveness.
TL;DR: Results show that overexpression of AIB1 promotes human HCC progression by enhancing cell proliferation and invasiveness and might be a useful molecular target for HCC prognosis and treatment.