J
Junke Zheng
Researcher at Shanghai Jiao Tong University
Publications - 69
Citations - 3098
Junke Zheng is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 20, co-authored 52 publications receiving 2335 citations. Previous affiliations of Junke Zheng include University of Texas at Dallas & University of Texas Southwestern Medical Center.
Papers
More filters
Journal ArticleDOI
The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche
Tugba Simsek,Fatih Kocabas,Junke Zheng,Ralph J. DeBerardinis,Ahmed I. Mahmoud,Eric N. Olson,Jay W. Schneider,Cheng Cheng Zhang,Hesham A. Sadek +8 more
TL;DR: It is shown that LT-HSCs utilize glycolysis instead of mitochondrial oxidative phosphorylation to meet their energy demands and that Meis1 regulates HSC metabolism through transcriptional activation of Hif-1alpha.
Journal ArticleDOI
Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development
Junke Zheng,Junke Zheng,Masato Umikawa,Masato Umikawa,Changhao Cui,Jiyuan Li,Xiaoli Chen,Chaozheng Zhang,Hoangdinh Hyunh,Xunlei Kang,Robert Silvany,Xuan Wan,Jingxiao Ye,Alberto Puig Cantó,Shu Hsia Chen,Huan You Wang,E. Sally Ward,Cheng Cheng Zhang +17 more
TL;DR: An unexpected functional significance of classical immune-inhibitory receptors in maintenance of stemness of normal adult stem cells and in support of cancer development is indicated.
Journal ArticleDOI
Meis1 regulates the metabolic phenotype and oxidant defense of hematopoietic stem cells
Fatih Kocabas,Junke Zheng,Junke Zheng,Suwannee Thet,Neal G. Copeland,Nancy A. Jenkins,Ralph J. DeBerardinis,Cheng Cheng Zhang,Hesham A. Sadek +8 more
TL;DR: It is demonstrated here that loss of Meis1 results in down-regulation of both Hif-1α and H if-2α in HSCs, which resulted in a shift to mitochondrial metabolism, increased reactive oxygen species production, and apoptosis of H SCs.
Journal ArticleDOI
LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration
Mi Deng,Xun Gui,Jaehyup Kim,Li Xie,Weina Chen,Zunling Li,Zunling Li,Licai He,Licai He,Yuanzhi Chen,Yuanzhi Chen,Heyu Chen,Weiguang Luo,Weiguang Luo,Zhigang Lu,Zhigang Lu,Jingjing Xie,Jingjing Xie,Hywyn Churchill,Yixiang Xu,Zhan Zhou,Guojin Wu,Chenyi Yu,Chenyi Yu,Samuel John,Kouyuki Hirayasu,Nam X. Nguyen,Xiaoye Liu,Fangfang Huang,Fangfang Huang,Leike Li,Hui Deng,Haidong Tang,Ali H. Sadek,Lingbo Zhang,Lingbo Zhang,Tao Huang,Yizhou Zou,Benjamin P C Chen,Hong Zhu,Hisashi Arase,Ningshao Xia,Youxing Jiang,Robert H. Collins,M. James You,Jade Homsi,Nisha Unni,Cheryl M. Lewis,Guo-Qiang Chen,Yang Xin Fu,X. Charlene Liao,Zhiqiang An,Junke Zheng,Ningyan Zhang,Cheng Cheng Zhang +54 more
TL;DR: It is shown that LILRB4, an immunoreceptor tyrosine-based inhibition motif-containing receptor and a marker of monocytic leukaemia, supports tumour cell infiltration into tissues and suppresses T cell activity via a signalling pathway that involves APOE, LIL RB4, SHP-2, uPAR and ARG1 in acute myeloid leukaemis (AML) cells.
Journal ArticleDOI
Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair
Shichuan Zhang,Hirohiko Yajima,Hoang Dinh Huynh,Junke Zheng,Elsa Callen,Hua Tang Chen,Nancy Wong,Samuel F. Bunting,Yu Fen Lin,Mengxia Li,Kyung Jone Lee,Michael D. Story,Eric J. Gapud,Barry P. Sleckman,André Nussenzweig,Cheng Cheng Zhang,David J. Chen,Benjamin P C Chen +17 more
TL;DR: Phosphorylation of DNA-PKcs is essential for activation of DNA damage repair and for the maintenance of tissue stem cell populations.