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Guojin Wu
Researcher at University of Texas Southwestern Medical Center
Publications - 36
Citations - 796
Guojin Wu is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Antibody & Biology. The author has an hindex of 12, co-authored 23 publications receiving 541 citations. Previous affiliations of Guojin Wu include China Agricultural University & University of Texas at Dallas.
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Journal ArticleDOI
LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration
Mi Deng,Xun Gui,Jaehyup Kim,Li Xie,Weina Chen,Zunling Li,Zunling Li,Licai He,Licai He,Yuanzhi Chen,Yuanzhi Chen,Heyu Chen,Weiguang Luo,Weiguang Luo,Zhigang Lu,Zhigang Lu,Jingjing Xie,Jingjing Xie,Hywyn Churchill,Yixiang Xu,Zhan Zhou,Guojin Wu,Chenyi Yu,Chenyi Yu,Samuel John,Kouyuki Hirayasu,Nam X. Nguyen,Xiaoye Liu,Fangfang Huang,Fangfang Huang,Leike Li,Hui Deng,Haidong Tang,Ali H. Sadek,Lingbo Zhang,Lingbo Zhang,Tao Huang,Yizhou Zou,Benjamin P C Chen,Hong Zhu,Hisashi Arase,Ningshao Xia,Youxing Jiang,Robert H. Collins,M. James You,Jade Homsi,Nisha Unni,Cheryl M. Lewis,Guo-Qiang Chen,Yang Xin Fu,X. Charlene Liao,Zhiqiang An,Junke Zheng,Ningyan Zhang,Cheng Cheng Zhang +54 more
TL;DR: It is shown that LILRB4, an immunoreceptor tyrosine-based inhibition motif-containing receptor and a marker of monocytic leukaemia, supports tumour cell infiltration into tissues and suppresses T cell activity via a signalling pathway that involves APOE, LIL RB4, SHP-2, uPAR and ARG1 in acute myeloid leukaemis (AML) cells.
Journal ArticleDOI
Inhibitory leukocyte immunoglobulin-like receptors: Immune checkpoint proteins and tumor sustaining factors.
TL;DR: This review aims to summarize current knowledge on expression patterns, ligands, signaling, and functions of LILRB family members in the context of cancer development and indicates that LIL RBs may represent ideal targets for tumor treatment.
Journal ArticleDOI
Fasting selectively blocks development of acute lymphoblastic leukemia via leptin-receptor upregulation
Zhigang Lu,Jingjing Xie,Jingjing Xie,Guojin Wu,Jinhui Shen,Robert H. Collins,Weina Chen,Xunlei Kang,Min Luo,Yizhou Zou,Lily Jun Shen Huang,James F. Amatruda,Tamra Slone,Naomi J. Winick,Philipp E. Scherer,Cheng Cheng Zhang,Cheng Cheng Zhang +16 more
TL;DR: Fasting alone robustly inhibits the initiation and reverses the leukemic progression of both B cell and T cell acute lymphoblastic leukemia, but not acute myeloid leukemia (AML), in mouse models of these tumors.
Journal ArticleDOI
Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation.
Guojin Wu,Ji-Bin Peng +1 more
TL;DR: It is concluded that KLHL3 is a substrate adaptor for WNK4 in a ubiquitin E3 ligase complex that causes pseudohypoaldosteronism II (PHAII), a hereditary form of hypertension.
Journal ArticleDOI
A Novel Anti-LILRB4 CAR-T Cell for the Treatment of Monocytic AML
Samuel John,Heyu Chen,Mi Deng,Xun Gui,Guojin Wu,Weina Chen,Zunling Li,Ningyan Zhang,Zhiqiang An,Cheng Cheng Zhang +9 more
TL;DR: It is demonstrated that leukocyte immunoglobulin-like receptor-B4 (LILRB4) is a tumor-associated antigen highly expressed on monocytic AML cells, and a novel anti-LilRB4 CAR-T cell that displays high antigen affinity and specificity is generated.