W
Werner Streicher
Researcher at Novozymes
Publications - 47
Citations - 2210
Werner Streicher is an academic researcher from Novozymes. The author has contributed to research in topics: Chemistry & Protein structure. The author has an hindex of 20, co-authored 43 publications receiving 1842 citations. Previous affiliations of Werner Streicher include Rensselaer Polytechnic Institute & Novo Nordisk Foundation.
Papers
More filters
Journal ArticleDOI
Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose).
Matthias Altmeyer,Matthias Altmeyer,Kai John Neelsen,Federico Teloni,Irina Pozdnyakova,Stefania Pellegrino,Merete Grøfte,Maj-Britt Rask,Werner Streicher,Werner Streicher,Stephanie Jungmichel,Michael L. Nielsen,Jiri Lukas +12 more
TL;DR: In vitro and in vivo, it is shown that the nucleic acid-mimicking biopolymer poly(ADP-ribose) (PAR) nucleates intracellular liquid demixing, which is a general mechanism to dynamically reorganize the soluble nuclear space with implications for pathological protein aggregation caused by derailed phase separation.
Journal ArticleDOI
Acetylation site specificities of lysine deacetylase inhibitors in human cells.
Christian Schölz,Brian T. Weinert,Sebastian A. Wagner,Petra Beli,Yasuyuki Miyake,Jun Qi,Lars Juhl Jensen,Werner Streicher,Anna R. McCarthy,Nicholas J. Westwood,Sonia Lain,Jürgen Cox,Patrick Matthias,Matthias Mann,James E. Bradner,Chunaram Choudhary +15 more
TL;DR: In this article, a comprehensive analysis of changes in protein acetylation in response to lysine deacetylase inhibitors uncovers inhibitor specificities, including specific inhibitors specificities.
Journal ArticleDOI
Direct binding between BubR1 and B56-PP2A phosphatase complexes regulate mitotic progression.
Thomas Kruse,Gang Zhang,Marie Sofie Yoo Larsen,Tiziana Lischetti,Werner Streicher,Tine K. Nielsen,Sara Petersen Bjørn,Jakob Nilsson +7 more
TL;DR: BubR1 directly binds to the B56 family of protein phosphatase 2A (PP2A) regulatory subunits through a conserved motif that is phosphorylated by cyclin-dependent kinase 1 (Cdk1) and polo-like kinases 1 (Plk1), and the data suggest that BubR1 counteracts Aurora B kinase activity at improperly attached kinetochores by recruiting B56– PP2A phosphatases complexes.
Journal ArticleDOI
RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response.
Sara L. Poulsen,Rebecca K. Hansen,Sebastian A. Wagner,Loes van Cuijk,Gijsbert J. van Belle,Werner Streicher,Mats Wikström,Chunaram Choudhary,Adriaan B. Houtsmuller,Jurgen A. Marteijn,Simon Bekker-Jensen,Niels Mailand +11 more
TL;DR: RNF111/Arkadia targets SUMOylated XPC for Ubiquitylation for ubiquitylation, negatively regulating its association with damaged DNA.
Journal ArticleDOI
Functional proteomics defines the molecular switch underlying FGF receptor trafficking and cellular outputs.
Chiara Francavilla,Kristoffer T.G. Rigbolt,Kristina B. Emdal,Gianni Carraro,Erik Vernet,Dorte B. Bekker-Jensen,Werner Streicher,Mats Wikström,Michael Sundström,Saverio Bellusci,Ugo Cavallaro,Blagoy Blagoev,Jesper V. Olsen +12 more
TL;DR: Results identify an intriguing ligand-dependent mechanism for the control of receptor fate and cellular outputs that may explain the pathogenic role of deregulated FGFR2b, thus offering therapeutic opportunities.