Wesley Abplanalp

TL;DR: Episodic PM2.5 exposures are associated with increased endothelial cell apoptosis, an antiangiogenic plasma profile, and elevated levels of circulating monocytes and T, but not B, lymphocytes, which could contribute to the pathogenic sequelae of atherogenesis and acute coronary events.

TL;DR: This poster presents a poster presented at the 2016 European Conference on Cardiovascular Regeneration and Cardiopulmonary Institute (ECAS) at the University of Heidelberg, Germany, on the topic of regenerative medicine and cardiothoracic surgery.

TL;DR: In this paper, the authors explore the kinetics and individual cellular responses of endothelial cells after myocardial infarction by using single cell RNA sequencing and demonstrate a time dependent switch in endothelial cell proliferation and inflammation associated with transient changes in metabolic gene signatures.

TL;DR: This study demonstrates that circulating monocytes and T cells of patients with HF harboring clonal hematopoiesis–driver mutations in DNMT3A exhibit a highly inflamed transcriptome, which may contribute to the aggravation of chronic HF.

TL;DR: Gene ontology term analyses of regulated genes revealed that the most significantly upregulated genes encode for leukocyte-activation and interleukin-signaling pathways in monocytes of individuals with DNMT3A (myeloid leukocytes activation), as well as the NLRP3 inflammasome complex, a cellular receptor capable of mediating infection, macrophage activation syndrome, and other genes involved in cytokine response syndrome.