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Yosif Manavski
Researcher at Goethe University Frankfurt
Publications - 22
Citations - 2220
Yosif Manavski is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Angiogenesis & Endothelial stem cell. The author has an hindex of 17, co-authored 21 publications receiving 1676 citations.
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Journal ArticleDOI
Long Noncoding RNA MALAT1 Regulates Endothelial Cell Function and Vessel Growth
Katharina M. Michalik,Xintian You,Yosif Manavski,Anuradha Doddaballapur,Martin Zörnig,Thomas Braun,David John,Yuliya Ponomareva,Wei Chen,Shizuka Uchida,Reinier A. Boon,Stefanie Dimmeler +11 more
TL;DR: Silencing of MALAT1 tips the balance from a proliferative to a migratory endothelial cell phenotype in vitro, and its genetic deletion or pharmacological inhibition reduces vascular growth in vivo.
Journal ArticleDOI
Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation
Konstantinos Stellos,Aikaterini Gatsiou,Kimon Stamatelopoulos,Ljubica Perisic Matic,David John,Federica Francesca Lunella,Nicolas Jaé,Oliver Rossbach,Carolin Amrhein,Frangiska Sigala,Reinier A. Boon,Boris Fürtig,Yosif Manavski,Xintian You,Shizuka Uchida,Till Keller,Jes Niels Boeckel,Anders Franco-Cereceda,Lars Maegdefessel,Wei Chen,Harald Schwalbe,Albrecht Bindereif,Per Eriksson,Ulf Hedin,Andreas M. Zeiher,Stefanie Dimmeler +25 more
TL;DR: It is shown that cathepsin S mRNA (CTSS), which encodes a cysteine protease associated with angiogenesis and atherosclerosis, is highly edited in human endothelial cells, revealing a previously unrecognized role of RNA editing in gene expression in human atherosclerotic vascular diseases.
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Laminar Shear Stress Inhibits Endothelial Cell Metabolism via KLF2-Mediated Repression of PFKFB3
Anuradha Doddaballapur,Katharina M. Michalik,Yosif Manavski,Tina Lucas,Riekelt H. Houtkooper,Xintian You,Wei Chen,Andreas M. Zeiher,Michael Potente,Stefanie Dimmeler,Reinier A. Boon +10 more
TL;DR: In this paper, the authors showed that shear stress exposure reduced glucose uptake and mitochondrial content in endothelium and showed that KLF2 overexpression recapitulates the inhibitory effects on endothelial glycolysis elicited by laminar flow.
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Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction
Lukas Tombor,David John,Simone F. Glaser,Guillermo Luxán,Elvira Forte,Milena B. Furtado,Nadia A. Rosenthal,Nina Baumgarten,Marcel H. Schulz,Janina Wittig,Eva-Maria Rogg,Yosif Manavski,Ariane Fischer,Marion Muhly-Reinholz,Kathrin Klee,Mario Looso,Carmen Selignow,Till Acker,Sofia-Iris Bibli,Ingrid Fleming,Ralph Patrick,Ralph Patrick,Richard P. Harvey,Richard P. Harvey,Wesley Abplanalp,Stefanie Dimmeler +25 more
TL;DR: In this paper, the authors explore the kinetics and individual cellular responses of endothelial cells after myocardial infarction by using single cell RNA sequencing and demonstrate a time dependent switch in endothelial cell proliferation and inflammation associated with transient changes in metabolic gene signatures.
Journal ArticleDOI
Histone Deacetylase 9 Promotes Angiogenesis by Targeting the Antiangiogenic MicroRNA-17–92 Cluster in Endothelial Cells
David Kaluza,Jens Kroll,Jens Kroll,Sabine Gesierich,Yosif Manavski,Jes Niels Boeckel,Carmen Doebele,Arthur Zelent,Lothar Rössig,Andreas M. Zeiher,Hellmut G. Augustin,Carmen Urbich,Stefanie Dimmeler +12 more
TL;DR: It is found that HDAC9 promotes angiogenesis and transcriptionally represses the microRNA (miR)-17–92 cluster, which is known for its antiangiogenic activity.