Exposure to Fine Particulate Air Pollution Is Associated With Endothelial Injury and Systemic Inflammation.
C. Arden Pope,Aruni Bhatnagar,James McCracken,Wesley Abplanalp,Daniel J. Conklin,Timothy E. O'Toole +5 more
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TLDR
Episodic PM2.5 exposures are associated with increased endothelial cell apoptosis, an antiangiogenic plasma profile, and elevated levels of circulating monocytes and T, but not B, lymphocytes, which could contribute to the pathogenic sequelae of atherogenesis and acute coronary events.Abstract:
Rationale:Epidemiological evidence indicates that exposures to fine particulate matter air pollution (PM2.5) contribute to global burden of disease, primarily as a result of increased risk of cardi...read more
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Exposure to air pollution and COVID-19 mortality in the United States: A nationwide cross-sectional study
TL;DR: A small increase in long-term exposure to PM2.5 leads to a large increase in the COVID-19 death rate, and the results underscore the importance of continuing to enforce existing air pollution regulations to protect human health both during and after the CO VID-19 crisis.
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Can atmospheric pollution be considered a co-factor in extremely high level of SARS-CoV-2 lethality in Northern Italy?
TL;DR: Evidence is provided that people living in an area with high levels of pollutant are more prone to develop chronic respiratory conditions and suitable to any infective agent, and the high level of pollution in Northern Italy should be considered an additional co-factor of the highlevel of lethality recorded in that area.
Journal ArticleDOI
Air pollution and COVID-19 mortality in the United States: Strengths and limitations of an ecological regression analysis.
TL;DR: One of the first preliminary investigations of whether long-term exposure to air pollution increases the severity of COVID-19 health outcomes, including death, is found, where it is found that higher historical PM2.5 exposures are positively associated with higher county-level CO VID-19 mortality rates after accounting for many area-level confounders.
Journal ArticleDOI
Cardiovascular effects of air pollution.
TL;DR: Experimental studies indicate that some pollutants have more harmful cardiovascular effects, such as combustion-derived PM2.5 and ultrafine particles, and promotion of safer air quality appears to be a new challenge in cardiovascular disease prevention.
Journal ArticleDOI
Environmental Determinants of Cardiovascular Disease.
TL;DR: An understanding of how different domains of the environment, individually and collectively, affect CVD risk could lead to a better appraisal of CVD and aid in the development of new preventive and therapeutic strategies to limit the increasingly high global burden of heart disease and stroke.
References
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TL;DR: In this paper, the authors estimated deaths and disability-adjusted life years (DALYs; sum of years lived with disability [YLD] and years of life lost [YLL]) attributable to the independent effects of 67 risk factors and clusters of risk factors for 21 regions in 1990 and 2010.
Journal ArticleDOI
Lung Cancer, Cardiopulmonary Mortality, and Long-term Exposure to Fine Particulate Air Pollution
C. Arden Pope,Richard T. Burnett,Michael J. Thun,Eugenia E. Calle,Daniel Krewski,Kazuhiko Ito,George D. Thurston +6 more
TL;DR: Fine particulate and sulfur oxide--related pollution were associated with all-cause, lung cancer, and cardiopulmonary mortality and long-term exposure to combustion-related fine particulate air pollution is an important environmental risk factor for cardiopULmonary and lung cancer mortality.
Journal ArticleDOI
An Association between Air Pollution and Mortality in Six U.S. Cities
Douglas W. Dockery,C A Pope rd,X Xu,John D. Spengler,James H. Ware,Martha E. Fay,Benjamin G. Ferris,Frank E. Speizer +7 more
TL;DR: It is suggested that fine-particulate air pollution, or a more complex pollution mixture associated with fine particulate matter, contributes to excess mortality in certain U.S. cities.
Journal ArticleDOI
Particulate Matter Air Pollution and Cardiovascular Disease An Update to the Scientific Statement From the American Heart Association
Robert D. Brook,Sanjay Rajagopalan,C. Arden Pope,Jeffrey R. Brook,Aruni Bhatnagar,Ana V. Diez-Roux,Fernando Holguin,Yuling Hong,Russell V. Luepker,Murray A. Mittleman,Annette Peters,David S. Siscovick,Sidney C. Smith,Laurie P. Whitsel,Joel D. Kaufman +14 more
TL;DR: It is the opinion of the writing group that the overall evidence is consistent with a causal relationship between PM2.5 exposure and cardiovascular morbidity and mortality.
Journal ArticleDOI
Cardiovascular Mortality and Long-Term Exposure to Particulate Air Pollution Epidemiological Evidence of General Pathophysiological Pathways of Disease
C. Arden Pope,Richard T. Burnett,George D. Thurston,Michael J. Thun,Eugenia E. Calle,Daniel Krewski,John J. Godleski +6 more
TL;DR: Fine particulate air pollution is a risk factor for cause-specific cardiovascular disease mortality via mechanisms that likely include pulmonary and systemic inflammation, accelerated atherosclerosis, and altered cardiac autonomic function.
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