W
William Fenical
Researcher at University of California, San Diego
Publications - 591
Citations - 36313
William Fenical is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Streptomyces & Laurencia. The author has an hindex of 97, co-authored 578 publications receiving 34003 citations. Previous affiliations of William Fenical include University of North Carolina at Chapel Hill & University of Concepción.
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Journal Article
The Biomedical Potential of California Marine Organisms
D.John Faulkner,William Fenical +1 more
TL;DR: Marine organisms comprise the greatest unexploited source of potential pharmaceuticals, and because of the unusual diversity of chemical structures isolated from marine organisms, there is great interest in screening marine natural products in new mechanism-based bioassays.
Journal ArticleDOI
Marinisporolides, Polyene‐Polyol Macrolides from a Marine Actinomycete of the New Genus Marinispora.
TL;DR: Marinisporolides are 34-membered macrolides composed of a conjugated pentaene and several pairs of 1,3-dihydroxyl functionalities as discussed by the authors.
Journal ArticleDOI
Prediction of seriniquinone-drug interactions by in vitro inhibition of human cytochrome P450 enzymes.
Rodrigo Moreira da Silva,Daniel Blascke Carrão,Maísa Daniela Habenschus,Paula C. Jimenez,Norberto Peporine Lopes,William Fenical,Letícia Vera Costa-Lotufo,Anderson Rodrigo Moraes de Oliveira +7 more
TL;DR: Investigation of the in vitro inhibitory effects of seriniquinone on the main human CYP450 isoforms involved in drug metabolism showed strong inhibition of CYP1A2, CYP2E1 and CYP3A, and moderate inhibition of CyP2C19, with IC50 value >15 μM.