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William Fenical
Researcher at University of California, San Diego
Publications - 591
Citations - 36313
William Fenical is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Streptomyces & Laurencia. The author has an hindex of 97, co-authored 578 publications receiving 34003 citations. Previous affiliations of William Fenical include University of North Carolina at Chapel Hill & University of Concepción.
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Journal ArticleDOI
Suppression of nitric oxide synthase by thienodolin in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells.
Eun-Jung Park,John M. Pezzuto,Kyoung Hwa Jang,Sang Jip Nam,Sergio A. Bucarey,William Fenical +5 more
TL;DR: Thienodolin inhibited nitric oxide production in LPS-stimulated RAW 264.7 cells and blocked the degradation of IκBα resulting in inhibition of NF-κB p65 nuclear translocation, and inhibited the phosphorylation of signal transducers and activators of transcription 1 (STAT1) at Tyr701.
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Saccharomonopyrones A-C, New α-Pyrones from a Marine Sediment-Derived Bacterium Saccharomonospora sp. CNQ-490.
Chae Yoon Yim,Tu Cam Le,Tae Gu Lee,Inho Yang,Han Sol Choi,Jusung Lee,Kyung Yun Kang,Jin Sil Lee,Kyung Min Lim,Sung Tae Yee,Heonjoong Kang,Sang Jip Nam,William Fenical +12 more
TL;DR: Intensive study of the organic extract of the marine-derived bacterium Saccharomonospora sp.
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The isolation of new norcycloartene triterpenoids from the tropical marine alga (chlorophyta)
TL;DR: Three Δ 3 -norcycloartene triterpenoids, with differing side chain functionalities, have been isolated from the tropical green alga Tydemania expeditionitis collected in Guam as discussed by the authors.
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Neomangicols: Structures and Absolute Stereochemistries of Unprecedented Halogenated Sesterterpenes from a Marine Fungus of the Genus Fusarium.
TL;DR: In this paper, three new sesterterpenes, neomangicols A−C (1−3), were isolated from the mycelial extract of a marine fungus belonging within the genus Fusarium, and the structures of the new metabolites were determined by 1D and 2D NMR methods.
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Lodopyridone, a Structurally Unprecedented Alkaloid from a Marine Actinomycete.
Katherine N. Maloney,John B. MacMillan,Christopher A. Kauffman,Paul R. Jensen,Antonio G. DiPasquale,Arnold L. Rheingold,William Fenical +6 more
TL;DR: In this paper, a marine Saccharomonospora sp., isolated from marine sediments collected at the mouth of the La Jolla Submarine Canyon, yielded the unprecedented alkaloid lodopyridone (1).