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William Fenical
Researcher at University of California, San Diego
Publications - 591
Citations - 36313
William Fenical is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Streptomyces & Laurencia. The author has an hindex of 97, co-authored 578 publications receiving 34003 citations. Previous affiliations of William Fenical include University of North Carolina at Chapel Hill & University of Concepción.
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Journal ArticleDOI
Pharmacological Properties of the Marine Natural Product Marinopyrrole A against Methicillin-Resistant Staphylococcus aureus
Nina M. Haste,Chambers C. Hughes,Dan N. Tran,William Fenical,William Fenical,Paul R. Jensen,Victor Nizet,Victor Nizet,Mary E. Hensler +8 more
TL;DR: It is shown that marinopyrrole A has potent concentration-dependent bactericidal activity against clinically relevant hospital- and community-acquired MRSA strains, a prolonged postantibiotic effect superior to that of the current first-line agents vancomycin and linezolid, and a favorable resistance profile.
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Evolution of Secondary Metabolite Genes in Three Closely Related Marine Actinomycete Species
TL;DR: The distribution and phylogenetic relationships of genes involved in the biosynthesis of secondary metabolites in the salinosporamide and staurosporine classes are examined to provide insight into the complex processes driving the evolution of secondary metabolism among closely related bacterial species.
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Thalassospiramides A and B, Immunosuppressive Peptides from the Marine Bacterium Thalassospira sp.
TL;DR: Two new cyclic peptides were isolated from a new member of the marine alpha-proteobacterium Thalassospira and bear unusual gamma-amino acids and show immunosuppressive activity in an interleukin-5 production inhibition assay.
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Antimicrobial activities of extracts from Indo-Pacific marine plants against marine pathogens and saprophytes
TL;DR: The antimicrobial effects of lipophilic and hydrophilic extracts from 54 species of marine algae and two species of seagrasses collected from Indo- Pacific reef habitats provide good evidence that antimicrobial chemical defenses are widespread among Indo-Pacific marine plants.