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William Fenical
Researcher at University of California, San Diego
Publications - 591
Citations - 36313
William Fenical is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Streptomyces & Laurencia. The author has an hindex of 97, co-authored 578 publications receiving 34003 citations. Previous affiliations of William Fenical include University of North Carolina at Chapel Hill & University of Concepción.
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Isolation and structure determination of the didemnenones, novel cytotoxic metabolites from tunicates
Niels Lindquist,William Fenical,David F. Sesin,Chris M. Ireland,Gregory D. Van Duyne,Craig J. Forsyth,Jon Clardy +6 more
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Zygosporamide, a cytotoxic cyclic depsipeptide from the marine-derived fungus Zygosporium masonii
TL;DR: Zygosporamide as mentioned in this paper, a cyclic pentadepsipeptide, was isolated from seawater-based fermentation broth of a marine-derived fungus identified as Zygospora masonii.
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A cyclic carbonate and related polyketides from a marine-derived fungus of the genus Phoma.
TL;DR: Two metabolites, phomoxin and phomoxide, have been isolated from the fermentation broth of a marine-derived fungus of the genus Phoma, which contains an unusual cyclic carbonate functionality that is rare among natural products.
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Cryptosphaerolide, a cytotoxic Mcl-1 inhibitor from a marine-derived ascomycete related to the genus Cryptosphaeria
Hyuncheol Oh,Paul R. Jensen,Brian T. Murphy,Catherine Fiorilla,John F. Sullivan,Timothy Ramsey,William Fenical +6 more
TL;DR: Examination of the saline fermentation products from the marine-derived ascomycete fungal strain CNL-523 resulted in the isolation of cryptosphaerolide, an ester-substituted sesquiterpenoid related to the eremophilane class, which was found to be an inhibitor of the protein Mcl-1, a cancer drug target involved in apoptosis.
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Effects of Caribbean sponge secondary metabolites on bacterial surface colonization
TL;DR: In this article, the authors used organic tissue extracts from 8 species of Caribbean sponges for inhibitory effects on surface colonization using 24 environmental marine bacterial isolates, 4 known marine invertebrate pathogens, and 1 common fouling bacterium.