William Fenical

TL;DR: Pestalone exhibits moderate in vitro cytotoxicity in the National Cancer Institute's 60 human tumor cell line screen and shows potent antibiotic activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium, indicating that pestalone should be evaluated in advanced models of infectious disease.

TL;DR: A culture-dependent approach was applied to sediments collected in the Republic of Palau from the intertidal zone to depths of 500 m, resulting in the isolation of 1,624 diverse gram-positive bacteria spanning 22 families, including many that appear to represent new taxa.

TL;DR: This study demonstrates that NPP enabled the rapid characterization of >10 chemically diverse ribosomal and nonribosomal peptide natural products of novel composition from streptomycete bacteria as a proof of concept to begin automating the genome mining process.

TL;DR: This review summarizes the chemical discoveries and biological activities reported from marine bacteria and focuses upon several microbiological topics as they relate to natural product discovery, including the distributions, diversity, and culturability of marine bacteria, as well as the role of symbiotic bacteria in the production of substances previously ascribed to other sources.

TL;DR: Continued efforts to characterize marine actinomycete diversity and how adaptations to the marine environment affect secondary metabolite production will create a better understanding of the potential utility of these bacteria as a source of useful products for biotechnology.