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William J. Murphy

Researcher at Texas A&M University

Publications -  320
Citations -  27304

William J. Murphy is an academic researcher from Texas A&M University. The author has contributed to research in topics: Genome & Immune system. The author has an hindex of 80, co-authored 293 publications receiving 25360 citations. Previous affiliations of William J. Murphy include Pontifícia Universidade Católica do Rio Grande do Sul & Texas College.

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Immunobiology of natural killer cells and bone marrow transplantation: merging of basic and preclinical studies

TL;DR: Natural killer cells mediate acute rejection of bone marrow, but not solid tissue, allografts in lethally irradiated mice, providing insights as to their physiological roles and points the way to potential clinical uses following BMT.
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Phylogenetic relationships within the aplocheiloid fish genus Rivulus (Cyprinodontiformes, Rivulidae): implications for Caribbean and Central American biogeography.

TL;DR: The phylogenetic relationships of 16 northern species of the aplocheiloid genus Rivulus inhabiting the Caribbean, Central America, and South America suggest that the extant Central American taxa represent the descendants of at least two separate invasions during the Cenozoic, prior to the closing of the Panamanian isthmus.
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Supermatrix and species tree methods resolve phylogenetic relationships within the big cats, Panthera (Carnivora: Felidae).

TL;DR: An alternative, highly supported interpretation of the evolutionary history of the pantherine lineage is provided using novel and published DNA sequence data from the autosomes, both sex chromosomes and the mitochondrial genome, which yields a robust consensus topology supporting the monophyly of lion and leopard, with jaguar sister to these species, as well as a sister species relationship of tiger and snow leopard.
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Recombination-Aware Phylogenomics Reveals the Structured Genomic Landscape of Hybridizing Cat Species.

TL;DR: It is concluded that existing phylogenomic approaches to infer the Tree of Life may be highly misleading without considering the genomic architecture of phylogenetic signal relative to recombination rate and its interplay with historical hybridization.
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Novel gene acquisition on carnivore Y chromosomes.

TL;DR: The discovery of four novel Y chromosome genes that do not have functional copies in the finished human male-specific region of the Y or on other mammalian Y chromosomes explored thus far demonstrates the gene novelty on this chromosome between mammalian orders.