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William J. Murphy
Researcher at Texas A&M University
Publications - 320
Citations - 27304
William J. Murphy is an academic researcher from Texas A&M University. The author has contributed to research in topics: Genome & Immune system. The author has an hindex of 80, co-authored 293 publications receiving 25360 citations. Previous affiliations of William J. Murphy include Pontifícia Universidade Católica do Rio Grande do Sul & Texas College.
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Journal ArticleDOI
The Promise of Comparative Genomics in Mammals
Stephen J. O'Brien,Marilyn Menotti-Raymond,William J. Murphy,William G. Nash,Johannes Wienberg,Roscoe Stanyon,Neal G. Copeland,Nancy A. Jenkins,James E. Womack,Jennifer A. Marshall Graves +9 more
TL;DR: Comparative genetic assessment expands the utility of dense genetic maps of human, mouse, and rat genomes in gene discovery, in functional genomics, and in tracking the evolutionary forces that sculpted the genome organization of modern mammalian species.
Journal ArticleDOI
Macroevolutionary dynamics and historical biogeography of primate diversification inferred from a species supermatrix
Mark S. Springer,Robert W. Meredith,Robert W. Meredith,John Gatesy,Christopher A. Emerling,Jong Hwan Park,Jong Hwan Park,Daniel L. Rabosky,Daniel L. Rabosky,Tanja Stadler,Cynthia C. Steiner,Oliver A. Ryder,Jan E. Janecka,Colleen A. Fisher,William J. Murphy +14 more
TL;DR: A robust molecular phylogeny for 70 primate genera and 367 primate species is generated based on a concatenation of 69 nuclear gene segments and ten mitochondrial gene sequences, most of which were extracted from GenBank to find support for the hypothesis that the most recent common ancestor of living Primates resided in Asia.
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Using genomic data to unravel the root of the placental mammal phylogeny
TL;DR: The genome sequence assemblies of human, armadillo, elephant, and opossum are analyzed to identify informative coding indels that would serve as rare genomic changes to infer early events in placental mammal phylogeny and suggest Afrotheria and Xenarthra diverged from other placental mammals approximately 103 (95-114) million years ago.
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Structure of the 5' ends of immunoglobulin genes: a novel conserved sequence
TL;DR: Comparison of the sequence of the 70Z/3 kappa light chain gene with those encoding other immunoglobulin heavy and light chains has revealed that a distinctive promoter region structure is characteristic of this multigene family.
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Initial sequence and comparative analysis of the cat genome
Joan Pontius,James C. Mullikin,Douglas Smith,Agencourt Sequencing Team,Kerstin Lindblad-Toh,Sante Gnerre,Michele Clamp,Jean Chang,Robert M. Stephens,Beena Neelam,Natalia Volfovsky,Alejandro A. Schäffer,Richa Agarwala,Kristina Narfström,William J. Murphy,Urs Giger,Alfred L. Roca,Agostinho Antunes,Agostinho Antunes,Marilyn Menotti-Raymond,Naoya Yuhki,Jill Pecon-Slattery,Warren E. Johnson,Guillaume Bourque,Glenn Tesler,Nisc Comparative Sequencing Program,Stephen J. O'Brien +26 more
TL;DR: The genome sequence of an inbred Abyssinian domestic cat was assembled, mapped, and annotated with a comparative approach that involved cross-reference to annotated genome assemblies of six mammals, shedding new light on the tempo and mode of gene/genome evolution in mammals and promising several research applications for the cat.