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William J. Murphy
Researcher at Texas A&M University
Publications - 320
Citations - 27304
William J. Murphy is an academic researcher from Texas A&M University. The author has contributed to research in topics: Genome & Immune system. The author has an hindex of 80, co-authored 293 publications receiving 25360 citations. Previous affiliations of William J. Murphy include Pontifícia Universidade Católica do Rio Grande do Sul & Texas College.
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Journal ArticleDOI
Mammalian phylogenomics comes of age
TL;DR: How comparative genomic data from mammals is progressing to resolve long-standing phylogenetic controversies, to refine dogma on how chromosomes evolve and to guide annotation of human and other vertebrate genomes is described.
Journal ArticleDOI
28-Way vertebrate alignment and conservation track in the UCSC Genome Browser
Webb Miller,Kate R. Rosenbloom,Ross C. Hardison,Minmei Hou,James Taylor,Brian J. Raney,Richard Burhans,David C. King,Robert Baertsch,Daniel Blankenberg,Sergei L. Kosakovsky Pond,Anton Nekrutenko,Belinda Giardine,Robert S. Harris,Svitlana Tyekucheva,Mark Diekhans,Thomas H. Pringle,William J. Murphy,Arthur M. Lesk,George M. Weinstock,Kerstin Lindblad-Toh,Richard A. Gibbs,Eric S. Lander,Adam Siepel,David Haussler,David Haussler,W. James Kent +26 more
TL;DR: A set of alignments of 28 vertebrate genome sequences that is provided by the UCSC Genome Browser is described, showing the power of this resource for exploring vertebrate and mammalian evolution, using three examples.
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Molecular and Genomic Data Identify the Closest Living Relative of Primates
Jan E. Janecka,Webb Miller,Thomas H. Pringle,Frank Wiens,Annette Zitzmann,Kristofer M. Helgen,Mark S. Springer,William J. Murphy +7 more
TL;DR: The data show that colugos are the closest living relatives of primates and indicate that their divergence occurred in the Cretaceous, and suggest that treeshrews arose approximately 63 million years ago.
Journal ArticleDOI
Sequencing the Mouse Y Chromosome Reveals Convergent Gene Acquisition and Amplification on Both Sex Chromosomes
Y. Q. Shirleen Soh,Jessica Alföldi,Tatyana Pyntikova,Laura G. Brown,Laura G. Brown,Tina Graves,Patrick Minx,Robert S. Fulton,Colin Kremitzki,Natalia Koutseva,Jacob L. Mueller,Steve Rozen,Jennifer F. Hughes,Elaine Owens,James E. Womack,William J. Murphy,Qing Cao,Pieter J. de Jong,Wesley C. Warren,Richard K. Wilson,Helen Skaletsky,Helen Skaletsky,David C. Page,David C. Page +23 more
TL;DR: The complete mouse MSY sequence brings to light dramatic forces in sex chromosome evolution: lineage-specific convergent acquisition and amplification of X-Y gene families, possibly fueled by antagonism between acquired X-y homologs.
Journal ArticleDOI
Genomics and conservation genetics
TL;DR: Genome sequence information and new technological and bioinformatics platforms now enable comprehensive surveys of neutral variation and more direct inferences of detrimental and adaptive variation in species with sequenced genomes and in 'genome-enabled' endangered taxa.