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William L. Brown
Researcher at Mayo Clinic
Publications - 18
Citations - 1098
William L. Brown is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Factor H & Complement system. The author has an hindex of 10, co-authored 18 publications receiving 998 citations.
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Journal ArticleDOI
Genetic variants near TIMP3 and high-density lipoprotein–associated loci influence susceptibility to age-related macular degeneration
Wei Chen,Dwight Stambolian,Albert O. Edwards,Kari Branham,Mohammad Othman,Johanna Jakobsdottir,Nirubol Tosakulwong,Margaret A. Pericak-Vance,Peter A. Campochiaro,Michael L. Klein,Perciliz L. Tan,Yvette P. Conley,Atsuhiro Kanda,Laura J. Kopplin,Yanming Li,Katherine J. Augustaitis,Athanasios J. Karoukis,William K. Scott,Anita Agarwal,Jaclyn L. Kovach,Stephen G. Schwartz,Eric A. Postel,Matthew Brooks,Keith H. Baratz,William L. Brown,Alexander J. Brucker,Anton Orlin,Gary C. Brown,Allen C. Ho,Carl D. Regillo,Larry A. Donoso,Lifeng Tian,Brian Kaderli,Dexter Hadley,Stephanie A. Hagstrom,Stephanie A. Hagstrom,Neal S. Peachey,Neal S. Peachey,Neal S. Peachey,Ronald Klein,Barbara E.K. Klein,Norimoto Gotoh,Kenji Yamashiro,Frederick L. Ferris,Jesen Fagerness,Robyn Reynolds,Lindsay A. Farrer,Ivana K. Kim,Joan W. Miller,Marta Corton,Angel Carracedo,Manuel Sánchez-Salorio,Elizabeth W. Pugh,Kimberly F. Doheny,Maria Brion,Margaret M. DeAngelis,Daniel E. Weeks,Donald J. Zack,Emily Y. Chew,John R. Heckenlively,Nagahisa Yoshimura,Sudha K. Iyengar,Peter J. Francis,Nicholas Katsanis,Johanna M. Seddon,Jonathan L. Haines,Michael B. Gorin,Gonçalo R. Abecasis,Anand Swaroop,Anand Swaroop +69 more
TL;DR: A genome-wide association scan for age-related macular degeneration (AMD) showed that 329 of 331 individuals with the highest-risk genotypes were cases, and 85% of these had advanced AMD, consistent with the hypothesis that HDL metabolism is associated with AMD pathogenesis.
Journal ArticleDOI
E2-2 Protein and Fuchs's Corneal Dystrophy
Keith H. Baratz,Nirubol Tosakulwong,Euijung Ryu,William L. Brown,Kari Branham,Wei Chen,Khoa D. Tran,Katharina E. Schmid-Kubista,John R. Heckenlively,Anand Swaroop,Gonçalo R. Abecasis,Kent R. Bailey,Albert O. Edwards +12 more
TL;DR: Genetic variation in TCF4 contributes to the development of FCD and is associated with typical and advanced FCD.
Journal ArticleDOI
Genetic control of the alternative pathway of complement in humans and age-related macular degeneration
Laura A. Hecker,Albert O. Edwards,Euijung Ryu,Nirubol Tosakulwong,Keith H. Baratz,William L. Brown,Peter Charbel Issa,Peter Charbel Issa,Hendrik P. N. Scholl,Beatrix Pollok-Kopp,Katharina E. Schmid-Kubista,Kent R. Bailey,Martin Oppermann +12 more
TL;DR: The data are consistent with a disease model in which genetic variation in the complement system increases the risk of AMD by a combination of systemic complement activation and abnormal regulation of complement activation in local tissues.
Journal ArticleDOI
Contribution of copy number variation in the regulation of complement activation locus to development of age-related macular degeneration.
Katharina E. Schmid-Kubista,Nirubol Tosakulwong,Yanhong Wu,Euijung Ryu,Laura A. Hecker,Keith H. Baratz,William L. Brown,Albert O. Edwards +7 more
TL;DR: Deletion of CFHR3 and CFHR1 protected against the development of AMD at least in part because the deletion tagged a protective haplotype and did not occur on the risk haplotype.
Journal ArticleDOI
Comprehensive assessment of genetic variants within TCF4 in Fuchs' endothelial corneal dystrophy.
Eric D. Wieben,Ross A. Aleff,Bruce W. Eckloff,Elizabeth J. Atkinson,Saurabh Baheti,Sumit Middha,William L. Brown,Sanjay V. Patel,Jean Pierre A. Kocher,Keith H. Baratz +9 more
TL;DR: Complete sequencing of the TCF4 genomic region revealed no single causative variant for FECD, and an intronic expansion of the repeating trinucleotides, TGC, continues to be more strongly associated with FECD than any other genetic variant.