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Anton Orlin
Researcher at Cornell University
Publications - 65
Citations - 3504
Anton Orlin is an academic researcher from Cornell University. The author has contributed to research in topics: Retinal detachment & Visual acuity. The author has an hindex of 17, co-authored 60 publications receiving 2825 citations. Previous affiliations of Anton Orlin include Rush University Medical Center & Hospital of the University of Pennsylvania.
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Journal ArticleDOI
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants
Lars G. Fritsche,Wilmar Igl,Jessica N. Cooke Bailey,Felix Grassmann,Sebanti Sengupta,Jennifer L. Bragg-Gresham,Kathryn P. Burdon,Scott J. Hebbring,Cindy Wen,Mathias Gorski,Ivana K. Kim,David Cho,Donald J. Zack,Donald J. Zack,Eric H. Souied,Hendrik P. N. Scholl,Hendrik P. N. Scholl,Elisa Bala,Kristine ELee,David J. Hunter,Rebecca J. Sardell,Paul Mitchell,Joanna E. Merriam,Valentina Cipriani,Valentina Cipriani,Joshua D. Hoffman,Tina Schick,Yara T. E. Lechanteur,Robyn H. Guymer,Matthew P. Johnson,Yingda Jiang,Chloe M. Stanton,Gabri'lle H.S. Buitendijk,Xiaowei Zhan,Xiaowei Zhan,Alan M. Kwong,Alexis Boleda,Matthew Brooks,Linn Gieser,Rinki Ratnapriya,Kari Branham,Johanna R. Foerster,John R. Heckenlively,Mohammad Othman,Brendan J. Vote,Helena Liang,Emmanuelle Souzeau,Ian L. McAllister,Timothy Isaacs,Janette Hall,Stewart Lake,David A. Mackey,David A. Mackey,David A. Mackey,Ian J. Constable,Jamie E Craig,Terrie Kitchner,Zhenglin Yang,Zhenglin Yang,Zhiguang Su,Hongrong Luo,Daniel Chen,Hong Ouyang,Ken Flagg,Danni Lin,Guanping Mao,Henry Ferreyra,Klaus Stark,Claudia N von Strachwitz,Armin Wolf,Caroline Brandl,G. Rudolph,Matthias Olden,Margaux A. Morrison,Denise J. Morgan,Matthew Schu,Jeeyun Ahn,Giuliana Silvestri,Evangelia E. Tsironi,Kyu Hyung Park,Lindsay A. Farrer,Anton Orlin,Alexander J. Brucker,Mingyao Li,Christine A. Curcio,Saddek Mohand-Sa'd,José-Alain Sahel,Isabelle Audo,Mustapha Benchaboune,Angela J. Cree,Christina A Rennie,S. V. Goverdhan,Michelle Grunin,Shira Hagbi-Levi,Peter A. Campochiaro,Nicholas Katsanis,Frank G. Holz,Frédéric Blond,Frédéric Blond,Frédéric Blond,Hél'ne Blanché,Jean Fran ois Deleuze,Robert P. Igo,Barbara Truitt,Neal S. Peachey,Neal S. Peachey,Stacy M. Meuer,Chelsea E. Myers,Emily L. Moore,Ronald Klein,Michael A. Hauser,Eric A. Postel,Monique D. Courtenay,Stephen G. Schwartz,Jaclyn L. Kovach,William K. Scott,Gerald Liew,Ava Grace Tan,Bamini Gopinath,John C. Merriam,R. Theodore Smith,R. Theodore Smith,Jane C. Khan,Jane C. Khan,Jane C. Khan,Humma Shahid,Humma Shahid,Anthony T. Moore,Anthony T. Moore,Anthony T. Moore,J Allie McGrath,Renee Laux,Milam A. Brantley,Anita Agarwal,Lebriz Ersoy,Albert Caramoy,Thomas Langmann,Nicole T.M. Saksens,Eiko Kde Jong,Carel B. Hoyng,Melinda Cain,Andrea J. Richardson,Tammy M. Martin,John Blangero,Daniel E. Weeks,Bal Dhillon,Cornelia M. van Duijn,Kimberly F. Doheny,Jane Romm,Caroline C W Klaver,Caroline Hayward,Michael B. Gorin,Michael L. Klein,Paul N. Baird,Anneke I. den Hollander,Sascha Fauser,John R. WYates,John R. WYates,John R. WYates,Rando Allikmets,Jie Jin Wang,Debra A. Schaumberg,Debra A. Schaumberg,Barbara E.K. Klein,Stephanie A. Hagstrom,Itay Chowers,Andrew J. Lotery,Thierry Léveillard,Thierry Léveillard,Thierry Léveillard,Kang Zhang,Kang Zhang,Murray H. Brilliant,Alex W. Hewitt,Alex W. Hewitt,Alex W. Hewitt,Anand Swaroop,Emily Y. Chew,Margaret A. Pericak-Vance,Margaret M. DeAngelis,Dwight Stambolian,Jonathan L. Haines,Sudha K. Iyengar,Bernhard H. F. Weber,Gon'alo R. Abecasis,Iris M. Heid +185 more
TL;DR: The results support the hypothesis that rare coding variants can pinpoint causal genes within known genetic loci and illustrate that applying the approach systematically to detect new loci requires extremely large sample sizes.
Journal ArticleDOI
Seven new loci associated with age-related macular degeneration
Lars G. Fritsche,Lars G. Fritsche,Wei Chen,Wei Chen,Matthew Schu,Brian L. Yaspan,Yi Yu,Gudmar Thorleifsson,Donald J. Zack,Donald J. Zack,Satoshi Arakawa,Valentina Cipriani,Valentina Cipriani,Stephan Ripke,Stephan Ripke,Robert P. Igo,Gabriëlle H.S. Buitendijk,Xueling Sim,Xueling Sim,Daniel E. Weeks,Robyn H. Guymer,Joanna E. Merriam,Peter J. Francis,Gregory Hannum,Anita Agarwal,Ana Maria Armbrecht,Isabelle Audo,Tin Aung,Tin Aung,Gaetano R. Barile,Mustapha Benchaboune,Alan C. Bird,Alan C. Bird,Paul N. Bishop,Kari Branham,Matthew Brooks,Alexander J. Brucker,William Cade,Melinda Cain,Peter A. Campochiaro,Chi-Chao Chan,Ching-Yu Cheng,Ching-Yu Cheng,Emily Y. Chew,Kimberly A Chin,Itay Chowers,David Clayton,Radu Cojocaru,Yvette P. Conley,Belinda K. Cornes,Mark J. Daly,Baljean Dhillon,Albert O. Edwards,Evangelos Evangelou,Jesen Fagerness,Jesen Fagerness,Henry Ferreyra,James S. Friedman,Asbjorg Geirsdottir,Ronnie George,Christian Gieger,Neel Gupta,Stephanie A. Hagstrom,Simon P. Harding,Christos Haritoglou,John R. Heckenlively,Frank G. Holz,Guy Hughes,John P. A. Ioannidis,Tatsuro Ishibashi,Peronne Joseph,Gyungah Jun,Yoichiro Kamatani,Nicholas Katsanis,Claudia N. Keilhauer,Jane C. Khan,Jane C. Khan,Jane C. Khan,Ivana K. Kim,Yutaka Kiyohara,Barbara E.K. Klein,Ronald Klein,Jaclyn L. Kovach,Igor Kozak,Clara Lee,Kristine E. Lee,Peter Lichtner,Andrew J. Lotery,Thomas Meitinger,Paul Mitchell,Saddek Mohand-Said,Anthony T. Moore,Anthony T. Moore,Denise J. Morgan,Margaux A. Morrison,Chelsea E. Myers,Adam C. Naj,Yusuke Nakamura,Yukinori Okada,Anton Orlin,M. Carolina Ortube,Mohammad Othman,Chris Pappas,Kyu Hyung Park,Gayle J.T. Pauer,Neal S. Peachey,Neal S. Peachey,Olivier Poch,Rinki Ratna Priya,Robyn Reynolds,Andrea J. Richardson,Raymond Ripp,G. Rudolph,Euijung Ryu,José-Alain Sahel,Debra A. Schaumberg,Hendrik P. N. Scholl,Hendrik P. N. Scholl,Stephen G. Schwartz,William K. Scott,Humma Shahid,Humma Shahid,Haraldur Sigurdsson,Giuliana Silvestri,Theru A. Sivakumaran,R. Theodore Smith,Lucia Sobrin,Eric H Souied,Dwight Stambolian,Hreinn Stefansson,Gwen M. Sturgill-Short,Atsushi Takahashi,Nirubol Tosakulwong,Barbara Truitt,Evangelia E. Tsironi,André G. Uitterlinden,Cornelia M. van Duijn,Lingam Vijaya,Johannes R. Vingerling,Eranga N. Vithana,Eranga N. Vithana,Andrew R. Webster,Andrew R. Webster,H.-Erich Wichmann,Thomas W. Winkler,Tien Yin Wong,Tien Yin Wong,Tien Yin Wong,Alan F. Wright,Diana Zelenika,Ming Zhang,Ming Zhang,Ling Zhao,Kang Zhang,Kang Zhang,Michael L. Klein,Gregory S. Hageman,Mark Lathrop,Kari Stefansson,Kari Stefansson,Rando Allikmets,Paul N. Baird,Michael B. Gorin,Jie Jin Wang,Jie Jin Wang,Caroline C W Klaver,Johanna M. Seddon,Margaret A. Pericak-Vance,Sudha K. Iyengar,John R.W. Yates,John R.W. Yates,John R.W. Yates,Anand Swaroop,Anand Swaroop,Bernhard H. F. Weber,Michiaki Kubo,Margaret M. DeAngelis,Thierry Léveillard,Thierry Léveillard,Thierry Léveillard,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Jonathan L. Haines,Lindsay A. Farrer,Iris M. Heid,Gonçalo R. Abecasis +185 more
TL;DR: A collaborative genome-wide association study, including >17,100 advanced AMD cases and >60,000 controls of European and Asian ancestry, identifies 19 loci associated at P < 5 × 10−8, which show enrichment for genes involved in the regulation of complement activity, lipid metabolism, extracellular matrix remodeling and angiogenesis.
Journal ArticleDOI
Genetic variants near TIMP3 and high-density lipoprotein–associated loci influence susceptibility to age-related macular degeneration
Wei Chen,Dwight Stambolian,Albert O. Edwards,Kari Branham,Mohammad Othman,Johanna Jakobsdottir,Nirubol Tosakulwong,Margaret A. Pericak-Vance,Peter A. Campochiaro,Michael L. Klein,Perciliz L. Tan,Yvette P. Conley,Atsuhiro Kanda,Laura J. Kopplin,Yanming Li,Katherine J. Augustaitis,Athanasios J. Karoukis,William K. Scott,Anita Agarwal,Jaclyn L. Kovach,Stephen G. Schwartz,Eric A. Postel,Matthew Brooks,Keith H. Baratz,William L. Brown,Alexander J. Brucker,Anton Orlin,Gary C. Brown,Allen C. Ho,Carl D. Regillo,Larry A. Donoso,Lifeng Tian,Brian Kaderli,Dexter Hadley,Stephanie A. Hagstrom,Stephanie A. Hagstrom,Neal S. Peachey,Neal S. Peachey,Neal S. Peachey,Ronald Klein,Barbara E.K. Klein,Norimoto Gotoh,Kenji Yamashiro,Frederick L. Ferris,Jesen Fagerness,Robyn Reynolds,Lindsay A. Farrer,Ivana K. Kim,Joan W. Miller,Marta Corton,Angel Carracedo,Manuel Sánchez-Salorio,Elizabeth W. Pugh,Kimberly F. Doheny,Maria Brion,Margaret M. DeAngelis,Daniel E. Weeks,Donald J. Zack,Emily Y. Chew,John R. Heckenlively,Nagahisa Yoshimura,Sudha K. Iyengar,Peter J. Francis,Nicholas Katsanis,Johanna M. Seddon,Jonathan L. Haines,Michael B. Gorin,Gonçalo R. Abecasis,Anand Swaroop,Anand Swaroop +69 more
TL;DR: A genome-wide association scan for age-related macular degeneration (AMD) showed that 329 of 331 individuals with the highest-risk genotypes were cases, and 85% of these had advanced AMD, consistent with the hypothesis that HDL metabolism is associated with AMD pathogenesis.
Journal ArticleDOI
Evidence of association of APOE with age-related macular degeneration: a pooled analysis of 15 studies.
Gareth J. McKay,Christopher Patterson,Usha Chakravarthy,Shilpa Dasari,Caroline C W Klaver,Johannes R. Vingerling,Lintje Ho,Paulus T. V. M. de Jong,Astrid E. Fletcher,Ian S. Young,Johan H. Seland,Mati Rahu,Gisèle Soubrane,Laura Tomazzoli,Fotis Topouzis,Jesús Vioque,Aroon D. Hingorani,Reecha Sofat,Michael Dean,Julie Sawitzke,Johanna M. Seddon,Inga Peter,Andrew R. Webster,Andrew R. Webster,Anthony T. Moore,Anthony T. Moore,John R.W. Yates,John R.W. Yates,John R.W. Yates,Valentina Cipriani,Valentina Cipriani,Lars G. Fritsche,Bernhard H. F. Weber,Claudia N. Keilhauer,Andrew J. Lotery,Andrew J. Lotery,Sarah Ennis,Michael L. Klein,Peter J. Francis,Dwight Stambolian,Anton Orlin,Michael B. Gorin,Daniel E. Weeks,Chia-Ling Kuo,Anand Swaroop,Anand Swaroop,Mohammad Othman,Atsuhiro Kanda,Wei Chen,Gonçalo R. Abecasis,Alan F. Wright,Caroline Hayward,Paul N. Baird,Robyn H. Guymer,John Attia,John Attia,Ammarin Thakkinstian,Giuliana Silvestri +57 more
TL;DR: In this paper, the association between apolipoprotein E (APOE), a lipid transport protein involved in low-density cholesterol modulation, and age-related macular degeneration (AMD) was investigated.
Evidence of association of APOE with age-related macular degeneration: a pooled analysis of 15 studies | NOVA. The University of Newcastle's Digital Repository
Gareth J. McKay,Christopher Patterson,Johan H. Seland,Mati Rahu,Gisele Soubrane,Laura Tomazzoli,Fotis Topouzis,Jesús Vioque,Aroon D. Hingorani,Reecha Sofat,Michael Dean,Julie Sawitzke,Usha Chakravarthy,Johanna M. Seddon,Inga Peter,Andrew R. Webster,Anthony T. Moore,John R.W. Yates,Valentina Cipriani,Lars G. Fritsche,Bernhard H. F. Weber,Claudia N. Keilhauer,Andrew J. Lotery,Shilpa Dasari,Sarah Ennis,Michael L. Klein,Peter J. Francis,Dwight Stambolian,Anton Orlin,Michael B. Gorin,Daniel E. Weeks,Chia-Ling Kuo,Anand Swaroop,Mohammad Othman,Caroline C W Klaver,Atsuhiro Kanda,Wei Chen,Goncalo R. Abecasis,A. F. Wright,Caroline Hayward,Paul N. Baird,Robyn H. Guymer,John Attia,Ammarin Thakkinstian,Giuliana Silvestri,Johannes R. Vingerling,Lintje Ho,Paulus T. V. M. de Jong,Astrid E. Fletcher,Ian S. Young +49 more
TL;DR: An expanded analysis substantially improves the understanding of the association between the APOE locus and AMD and provides evidence supporting the role of cholesterol modulation, and low‐density cholesterol specifically, in AMD disease etiology.