Marta Corton

TL;DR: A genome-wide association scan for age-related macular degeneration (AMD) showed that 329 of 331 individuals with the highest-risk genotypes were cases, and 85% of these had advanced AMD, consistent with the hypothesis that HDL metabolism is associated with AMD pathogenesis.

TL;DR: The paraoxonase -108 C-->T variant and the ApaI polymorphism in the IGF2 gene are associated with PCOS and might contribute to increased oxidative stress, insulin resistance, and hyperandrogenism in this prevalent disorder.

TL;DR: The differences in the gene expression profiles in visceral adipose tissue of PCos patients compared with nonhyperandrogenic women involve multiple genes related to several biological pathways, suggesting that the involvement of abdominal obesity in the pathogenesis of PCOS is more ample than previously thought and is not restricted to the induction of insulin resistance.

TL;DR: The epidemiological evidence, potential pathophysiological mechanisms and therapeutic implications of the association between DM and colorectal cancer, and the biological plausibility of a cause-and-effect relationship through characterization of the molecular pathways involved are reviewed.

TL;DR: The genotyping microarray combined with segregation and sequence analysis allowed us to identify the causative mutations in 11% of the families, and Retinol Dehydrogenase 12 was the most frequently mutated gene in the juvenile RP group, and Usher Syndrome 2A and Ceramide Kinase-Like were the mostrequently mutated genes in the typical RP group.