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William N. Charman
Researcher at Monash University
Publications - 199
Citations - 18654
William N. Charman is an academic researcher from Monash University. The author has contributed to research in topics: Lymphatic system & Bioavailability. The author has an hindex of 65, co-authored 199 publications receiving 17219 citations. Previous affiliations of William N. Charman include Chicago College of Osteopathic Medicine & University of Nebraska Medical Center.
Papers
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Journal ArticleDOI
Evaluation of the mass balance assumption with respect to the two‐resistance model of intestinal absorption by using in situ single‐pass intestinal perfusion of theophylline in rats
TL;DR: Methods of analyzing drug absorption data from rat intestinal-perfusion experiments are discussed in terms of mass-transfer resistances, or reciprocal permeabilities, and mass balances to indicate that models based on the two-resistance theory can lead to overestimation of P*eff by the ratio of the drugmass leaving the perfusate to the drug mass appearing in the plasma.
Patent
1,2,4-trioxolane antimalarials
Vennerstrom Jonathan L,Jacques Chollet,Yuxiang Dong,Hugues Matile,Maniyan Padmanilayam,Tang Yuanqing,William N. Charman +6 more
TL;DR: In this article, a means and method for treating malaria, schistosomiasis, and cancer using a spiro or dispiro 1,2,4-trioxolane is described.
Journal ArticleDOI
Validation of a Peptide Map for Recombinant Porcine Growth Hormone and Application to Stability Assessment
TL;DR: The utility and limitations of the mapping procedure for the determination of the reaction kinetics for pGH are demonstrated by assessing chemical changes in pGH induced by incubation at elevated pH.
Journal ArticleDOI
Tissue uptake of DDT is independent of chylomicron metabolism.
Natalie L. Trevaskis,Patrick Tso,Therese Rider,William N. Charman,Christopher J.H. Porter,Ronald J. Jandacek +5 more
TL;DR: DDT is absorbed predominantly via the intestinal lymphatic system in association with CM and accumulates in fatty tissues and demonstrates that the uptake of DDT into tissues is faster than and independent of the uptakeof CM core lipid (using CE as a marker).
Patent
Antimalarial compounds with flexible side-chains
Bongkoch Tarnchompoo,Yongyuth Yuthavong,Tirayut Vilaivan,Penchit Chitnumsub,Chawanee Thongpanchang,Kamchonwongpaisan Sumalee,David Matthews,Livia Vivas,Jirundon Yuvaniyama,Charman Susan A,William N. Charman,Sanjay Katiyar +11 more
TL;DR: In this article, the authors proposed a novel compound that is an inhibitor of wild type and mutant dihydrofolate reductase (DHFR) of Plasmodium falciparum, which is useful for the treatment of malaria.