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William N. Charman
Researcher at Monash University
Publications - 199
Citations - 18654
William N. Charman is an academic researcher from Monash University. The author has contributed to research in topics: Lymphatic system & Bioavailability. The author has an hindex of 65, co-authored 199 publications receiving 17219 citations. Previous affiliations of William N. Charman include Chicago College of Osteopathic Medicine & University of Nebraska Medical Center.
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Journal ArticleDOI
Association of Halofantrine with Postprandially Derived Plasma Lipoproteins Decreases Its Clearance Relative To Administration in the Fasted State
TL;DR: It is confirmed that the clearance of Hf is influenced by plasma lipoprotein profiles, and the findings have implications for the design and interpretation of fed/fasted bioavailability studies of lipophilic drugs and determination of their intrinsic pharmacokinetic parameters in subjects or patients with dyslipidemic profiles.
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The effect of drug lipophilicity and lipid vehicles on the lymphatic absorption of various testosterone esters
TL;DR: There appeared to be a significant vehicle effect on lymphatic absorption when monitoring the lymphatic transport of testosterone undecanoate after its oral administration in various lipid vehicles, and it did appear to be the major determinant of the bioavailability of orally administered testosterone undECanoate.
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Murine GPRC6A Mediates Cellular Responses to L-Amino Acids, but Not Osteocalcin Variants
Patricia Rueda,Elizabeth Harley,Yao Lu,Gregory D. Stewart,Stewart A. Fabb,Natalie Diepenhorst,Béatrice Cremers,Marie-Hélène Rouillon,Isabelle Wehrle,Anne Géant,Gwladys Lamarche,Katie Leach,William N. Charman,Arthur Christopoulos,Roger J. Summers,Patrick M. Sexton,Christopher J. Langmead +16 more
TL;DR: The results confirm that basic L-amino acids act as agonists of the murine GPRC6A receptor in both recombinant cells and immortalised entero-endocrine and pancreatic β-cells, and support a role for OCN as a direct ligand for mouse GPRc6A, suggesting that the reported in vivo effects of OCN may be indirect, rather than via direct activation of the receptor.
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The interaction of lipophilic drugs with intestinal fatty acid-binding protein
Tony Velkov,Sara Chuang,Jerome Wielens,Haralambos Harry Sakellaris,William N. Charman,Christopher J.H. Porter,Martin J. Scanlon +6 more
TL;DR: The binding of non-fatty acid lipophilic drugs to I-FABP may increase the cytosolic solubility of these compounds and thereby facilitate drug transport from the intestinal lumen across the enterocyte to sites of distribution and metabolism.
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Absorption of Danazol After Administration to Different Sites of the Gastrointestinal Tract and the Relationship to Single‐ and Double‐Peak Phenomena in the Plasma Profiles
TL;DR: Qualitative assessment identified the presence of double peaks or major shouldering characteristics in 14 of the 16 individual danazol plasma concentration‐time profiles, whereas only single peaks were present after intraintestinal administration, consistent with the double peaking phenomena after oral administration of the emulsion formulation being stomach‐related.