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William N. Charman
Researcher at Monash University
Publications - 199
Citations - 18654
William N. Charman is an academic researcher from Monash University. The author has contributed to research in topics: Lymphatic system & Bioavailability. The author has an hindex of 65, co-authored 199 publications receiving 17219 citations. Previous affiliations of William N. Charman include Chicago College of Osteopathic Medicine & University of Nebraska Medical Center.
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Journal ArticleDOI
Using the polymer partitioning method to probe the thermodynamic activity of poorly water‐soluble drugs solubilized in model lipid digestion products
TL;DR: The ability to measure drug activity in model digestive systems has potential for application in the rational development of improved lipid-based formulations of poorly water-soluble drugs for oral administration.
Journal ArticleDOI
Isoform-Specific Biased Agonism of Histamine H3 Receptor Agonists
Darren Riddy,Anna E. Cook,Natalie Diepenhorst,Sanja Bosnyak,Ryan Brady,Clotilde Mannoury la Cour,Elisabeth Mocaer,Roger J. Summers,William N. Charman,Patrick M. Sexton,Arthur Christopoulos,Christopher J. Langmead +11 more
TL;DR: To the best of the authors' knowledge, this is the first quantitative example of differential biased signaling via isoforms of the same G protein–coupled receptor that are simultaneously expressed in vivo and gives rise to the possibility of selective pharmacological targeting of individual receptor splice variants.
Journal ArticleDOI
Probing the Flexibility of the DsbA Oxidoreductase from Vibrio cholerae—a 15N - 1H Heteronuclear NMR Relaxation Analysis of Oxidized and Reduced Forms of DsbA
James Horne,Edward J. d’Auvergne,Murray Coles,Tony Velkov,Yanni K.-Y. Chin,William N. Charman,Richard John Prankerd,Paul R. Gooley,Martin J. Scanlon +8 more
TL;DR: Data collected and analyzed using a model-free approach provide compelling evidence of a role for dynamics in the catalytic cycle of DsbA.
Journal ArticleDOI
Intestinal Lymph Flow, and Lipid and Drug Transport Scale Allometrically From Pre-clinical Species to Humans.
Natalie L. Trevaskis,Given Lee,Alistair B.J. Escott,Alistair B.J. Escott,Kian Liun Phang,Kian Liun Phang,Jiwon Hong,Enyuan Cao,Kasiram Katneni,Susan A. Charman,Sifei Han,William N. Charman,Anthony R. J. Phillips,John A. Windsor,John A. Windsor,Christopher J.H. Porter +15 more
TL;DR: It is proposed that intestinal lymphatic flow, and lymphatic lipid and drug transport in humans is most similar to species with higher body mass such as dogs and underestimated by studies in rodents.
Book ChapterDOI
Model systems for intestinal lymphatic transport studies.
TL;DR: Although intestinal lymphatic drug transport leads directly to an increase in oral bioavailability, it also confers other potential advantages such as avoidance of hepatic first-pass metabolism, direct targeting to the associated lymphoid tissue, and indirect targeting to specific sites.