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William N. Charman
Researcher at Monash University
Publications - 199
Citations - 18654
William N. Charman is an academic researcher from Monash University. The author has contributed to research in topics: Lymphatic system & Bioavailability. The author has an hindex of 65, co-authored 199 publications receiving 17219 citations. Previous affiliations of William N. Charman include Chicago College of Osteopathic Medicine & University of Nebraska Medical Center.
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Journal ArticleDOI
Lipid-based vehicles for the oral delivery of poorly water soluble drugs
TL;DR: This review attempts to provide a framework for the assessment of lipid based formulations by describing how aspects of GI physiology, and the choice of lipids and their formulation attributes, impact on dose form performance.
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Lipids, lipophilic drugs, and oral drug delivery-some emerging concepts.
TL;DR: This mini-review describes some emerging formulation and biopharmaceutic strategies that hold promise for better understanding how to design and evaluate lipid-based dose forms.
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Self-emulsifying drug delivery systems: formulation and biopharmaceutic evaluation of an investigational lipophilic compound.
Susan A. Charman,William N. Charman,Mark Rogge,Terry D. Wilson,Frank J. Dutko,Colin W. Pouton +5 more
TL;DR: Self-emulsifying drug delivery systems (SEDDSs) represent a possible alternative to traditional oral formulations of lipophilic compounds and improved the reproducibility of the plasma profile in terms of the maximum plasma concentration (Cmax) and the time to reach the maximum concentration (tmax).
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In vitro assessment of oral lipid based formulations.
TL;DR: The utility of modified dissolution media to predict the impact of food on the absorption of poorly water soluble, lipophilic drugs, is explored and the use of lipid digestion models which have found increasing application in assessment of the interaction of digestible dose forms with the gastrointestinal milieu are contrasted.
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Formulation design and bioavailability assessment of lipidic self-emulsifying formulations of halofantrine
Shui-Mei Khoo,Andrew J. Humberstone,Christopher J.H. Porter,Glenn A. Edwards,William N. Charman +4 more
TL;DR: In this article, the potential for lipidic self-emulsifying drug delivery systems (SEDDS) and self-micro-emulsion drug delivery system (SMEDDS), to improve the oral bioavailability of a poorly absorbed, antimalarial drug (Halofantrine, Hf) was investigated in fasted beagles.