W
William N. Charman
Researcher at Monash University
Publications - 199
Citations - 18654
William N. Charman is an academic researcher from Monash University. The author has contributed to research in topics: Lymphatic system & Bioavailability. The author has an hindex of 65, co-authored 199 publications receiving 17219 citations. Previous affiliations of William N. Charman include Chicago College of Osteopathic Medicine & University of Nebraska Medical Center.
Papers
More filters
Journal ArticleDOI
Drug solubilization behavior during in vitro digestion of suspension formulations of poorly water-soluble drugs in triglyceride lipids.
TL;DR: Suspensions of drugs, which are poorly soluble in water and TG lipid, may prove beneficial as the relatively high solubilizing capacity of the colloidal phases produced on TG digestion will likely exceed the mass of drug that could have been administered as a simple lipid solution, however, for more lipid-soluble drugs, suspension formulations may offer little benefit.
Journal ArticleDOI
Computational prediction of formulation strategies for beyond-rule-of-5 compounds ☆
Christel A. S. Bergström,Christel A. S. Bergström,William N. Charman,Christopher J.H. Porter +3 more
TL;DR: Computational biopharmaceutical profiling can be used to identify where non-conventional gateways, such as prediction of 'formulate-ability' during lead optimisation and early development stages, are important and may ultimately increase the number of orally tractable contemporary targets.
Journal ArticleDOI
Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes.
Yuxiang Dong,Jacques Chollet,Hugues Matile,Susan A. Charman,Francis C. K. Chiu,William N. Charman,Bernard Scorneaux,Heinrich Urwyler,Josefina Santo Tomas,Christian Scheurer,Christopher Snyder,Arnulf Dorn,Xiaofang Wang,Jean M. Karle,Yuanqing Tang,Sergio Wittlin,Reto Brun,Jonathan L. Vennerstrom +17 more
TL;DR: The trioxolanes were substantially less effective in a standard oral suspension formulation compared to a solubilizing formulation and were more active when administered subcutaneously than orally, both of which suggest substantial biopharmaceutical liabilities.
Journal ArticleDOI
Relationship between Antimalarial Activity and Heme Alkylation for Spiro- and Dispiro-1,2,4-Trioxolane Antimalarials
Darren J. Creek,William N. Charman,Francis C. K. Chiu,Richard John Prankerd,Yuxiang Dong,Jonathan L. Vennerstrom,Susan A. Charman +6 more
TL;DR: Under standardized reaction conditions, a correlation was found between the extent of hemeAlkylation and in vitro antimalarial activity, suggesting that heme alkylation may be related to the mechanism of action for these trioxolanes.
Journal ArticleDOI
Lipophilic prodrugs designed for intestinal lymphatic transport
TL;DR: Examples of lipophilic prodrugs designed to avoid pre-systemic clearance, reduce gastrointestinal intolerance, and for targeting various disease states resident within the intestinal lymphatics are presented.