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William N. Charman
Researcher at Monash University
Publications - 199
Citations - 18654
William N. Charman is an academic researcher from Monash University. The author has contributed to research in topics: Lymphatic system & Bioavailability. The author has an hindex of 65, co-authored 199 publications receiving 17219 citations. Previous affiliations of William N. Charman include Chicago College of Osteopathic Medicine & University of Nebraska Medical Center.
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Journal ArticleDOI
Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target
Yongyuth Yuthavong,Bongkoch Tarnchompoo,Tirayut Vilaivan,Penchit Chitnumsub,Sumalee Kamchonwongpaisan,Susan A. Charman,Danielle N McLennan,Karen L. White,Livia Vivas,Emily Bongard,Chawanee Thongphanchang,Supannee Taweechai,Jarunee Vanichtanankul,Roonglawan Rattanajak,Uthai Arwon,Pascal Fantauzzi,Jirundon Yuvaniyama,William N. Charman,David Matthews +18 more
TL;DR: The use of cocrystal structures with inhibitors and substrates, along with efficacy and pharmacokinetic profiling for the design, characterization, and preclinical development of a selective, highly efficacious, and orally available antimalarial drug candidate that potently inhibits both wild-type and clinically relevant mutated forms of Plasmodium falciparum (Pf) DHFR.
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Identification of a Metabolically Stable Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Antimalarial Activity in Mice
Ramesh Gujjar,Alka Marwaha,Farah El Mazouni,John H. White,Karen L. White,Sharon A. Creason,David M. Shackleford,Jeffrey Baldwin,William N. Charman,Frederick S. Buckner,Susan A. Charman,Pradip Rathod,Margaret A. Phillips +12 more
TL;DR: This study provides the first proof of concept that DH ODH inhibitors can suppress Plasmodium growth in vivo, validating DHODH as a new target for antimalarial chemotherapy.
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Use of in vitro lipid digestion data to explain the in vivo performance of triglyceride-based oral lipid formulations of poorly water-soluble drugs: Studies with halofantrine
Christopher J.H. Porter,Ann Marie Kaukonen,Agnes Taillardat-Bertschinger,Benjamin James Boyd,Jacquelyn Michelle O'Connor,Glenn A. Edwards,William N. Charman +6 more
TL;DR: The potential utility of in vitro digestion models to assess and rank order the in vivo performance of lipid solution and suspension formulations of poorly water-soluble drugs such as Hf is demonstrated.
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Drug solubilization behavior during in vitro digestion of simple triglyceride lipid solution formulations.
TL;DR: The solubilization behavior of lipophilic drugs on digestion of simple TG lipid formulations is a function of the lipophilicity of the drug, the nature of the colloidal phases produced on digestionof the different formulation lipids, and the kinetics of drug transfer between the digesting formulation and the colloid phases produced.
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Separation and Characterization of the Colloidal Phases Produced on Digestion of Common Formulation Lipids and Assessment of Their Impact on the Apparent Solubility of Selected Poorly Water-Soluble Drugs
TL;DR: The need to consider the colloidal species that form in the small intestine during the digestion of common formulation lipids and the coincident enhancement in drug solubilization provided under these circumstances is highlighted.