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William N. Charman
Researcher at Monash University
Publications - 199
Citations - 18654
William N. Charman is an academic researcher from Monash University. The author has contributed to research in topics: Lymphatic system & Bioavailability. The author has an hindex of 65, co-authored 199 publications receiving 17219 citations. Previous affiliations of William N. Charman include Chicago College of Osteopathic Medicine & University of Nebraska Medical Center.
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Journal ArticleDOI
Effect of Altered Serum Lipid Concentrations on the IC50 of Halofantrine against Plasmodium Falciparum
TL;DR: The data indicate that consideration should be given to the adoption of standard conditions for the collection of serum with respect to pre- or postprandial states, and that subject- and disease-related factors which alter plasma lipoprotein profiles should be considered when interpreting the IC50 profile of Hf.
Journal ArticleDOI
Evaluation of emulsifiable glasses for the oral administration of cyclosporin in beagle dogs
Christopher J.H. Porter,Susan A. Charman,Rachel Williams,Margarita V. Bakalova,William N. Charman +4 more
TL;DR: These studies demonstrate the utility of EG technology for the oral delivery of cyclosporin, and develop the technology to include surfactant enhanced systems which offer improved characteristics.
Journal ArticleDOI
Divergent effects of strontium and calcium-sensing receptor positive allosteric modulators (calcimimetics) on human osteoclast activity
Natalie Diepenhorst,Katie Leach,Andrew N. Keller,Patricia Rueda,Anna E. Cook,Tracie L. Pierce,Cameron J. Nowell,Philippe Pastoureau,Massimo Sabatini,Roger J. Summers,William N. Charman,Patrick M. Sexton,Arthur Christopoulos,Christopher J. Langmead +13 more
TL;DR: It is not known whether bone‐targeted CaS receptor positive allosteric modulators (PAMs; calcimimetics) represent an alternative (or adjunctive) therapy to strontium (Sr2+o).
Journal ArticleDOI
The application of capillary electrophoresis for monitoring effects of excipients on protein conformation.
TL;DR: The utility of CE for monitoring the effects of neutral excipients on the thermal denaturation of a model protein under selected conditions is supported, but the widespread utility of the technique may be limited by the narrow temperature range of most commercial CE instruments and the need to use extreme pH conditions to monitor the complete denaturation transition.