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William N. Charman
Researcher at Monash University
Publications - 199
Citations - 18654
William N. Charman is an academic researcher from Monash University. The author has contributed to research in topics: Lymphatic system & Bioavailability. The author has an hindex of 65, co-authored 199 publications receiving 17219 citations. Previous affiliations of William N. Charman include Chicago College of Osteopathic Medicine & University of Nebraska Medical Center.
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Journal ArticleDOI
Bile increases intestinal lymphatic drug transport in the fasted rat.
TL;DR: Biliary-derived endogenous FA has a higher propensity to support lymphatic transport of Hf compared to other sources of endogenous FA, and the results suggest that this is related to the disparate trafficking of these alternate sources of exogenous FA within the enterocyte.
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Interaction between calcium, a model divalent cation, and a range of poly(acrylic acid) resins as a function of solution ph
TL;DR: The interaction between calcium, a small divalent cation, and selected polyacrylic acid polymers has been studied in this article, where the addition of calcium chloride to dispersions of the polymer reduced the maximal viscosity through an interaction which was not dependent upon physical entrapment of the cation by the viscous medium.
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Lymphatic appearance of DDT in thoracic or mesenteric lymph duct cannulated rats
TL;DR: The results of the study confirm that the lymphatic route is an important pathway for DDT absorption following oral dosing, and that collection of thoracic lymph overestimates the extent of direct intestinal lymphatic absorption of DDT after oral administration.
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Intestinal lymphatic transport enhances the post-prandial oral bioavailability of a novel cannabinoid receptor agonist via avoidance of first-pass metabolism.
Natalie L. Trevaskis,David M. Shackleford,William N. Charman,Glenn A. Edwards,Anne Gardin,Silke Appel-Dingemanse,Olivier Kretz,Bruno Galli,Christopher J.H. Porter +8 more
TL;DR: The positive food effect for CRA13 does not appear to result from increased post-prandial absorption, and is one of the first examples of a significant increase in bioavailability for a highly lipophilic drug, which is stimulated via almost complete post- prandial transport into the lymph, in turn resulting in a reduction in first-pass metabolism.
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Kinetics of iron-mediated artemisinin degradation: Effect of solvent composition and iron salt
Darren J. Creek,Francis C. K. Chiu,Richard John Prankerd,Susan A. Charman,William N. Charman +4 more
TL;DR: The significant effects observed in the current study highlight the need to carefully control reaction conditions when studying peroxide antimalarial stability or attempting to develop in vitro/in vivo correlations of endoperoxide antimoarials and their reactivity with iron.