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William N. Charman
Researcher at Monash University
Publications - 199
Citations - 18654
William N. Charman is an academic researcher from Monash University. The author has contributed to research in topics: Lymphatic system & Bioavailability. The author has an hindex of 65, co-authored 199 publications receiving 17219 citations. Previous affiliations of William N. Charman include Chicago College of Osteopathic Medicine & University of Nebraska Medical Center.
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Journal ArticleDOI
Kinetics of rearrangement and hydrolysis of amino acid derivatives of prazosin
TL;DR: In the absence of a free α-amino group, greater stabilization was achieved and the primary route of degradation at all pH values was hydrolysis of the amide bond to give prazosin.
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An acute and coincident increase in FABP expression and lymphatic lipid and drug transport occurs during intestinal infusion of lipid-based drug formulations to rats.
Natalie L. Trevaskis,Chunmin C. Lo,Li Yun Ma,Patrick Tso,Helen Irving,Christopher J.H. Porter,William N. Charman +6 more
TL;DR: The expression and intracellular distribution of I-FABP and L-FabP are acutely influenced by lipid infusion over a time period relevant to feeding or the administration of pharmaceutical lipidic formulations, and these changes occur coincidentally with increased drug transport into the lymphatics.
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Protein transport across hydrated hyaluronic acid ester membranes: Evaluation of ribonuclease A as a potentially useful model protein
TL;DR: Investigation of ribonuclease A (RNase A) as a potential model protein for probing mechanisms of protein release from matrices composed of partially esterified hyaluronic acid found it to have excellent aqueous stability and permeated hyaluronate membranes with no apparent changes in protein size.
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Lymphatic fatty acids in canines dosed with pharmaceutical formulations containing structured triacylglycerols
René Holm,Trine Porsgaard,Christopher J.H. Porter,Carl-Erik Høy,Glenn A. Edwards,Anette Müllertz,Henning G. Kristensen,William N. Charman +7 more
TL;DR: Results indicated that the fatty acid profile and intramolecular structure of administered TAG influenced the absorption of fatty acids in canines, also when the TAG was incorporated into a pharmaceutical formulation in low amounts.