William N. Charman

TL;DR: The quantities of long chain lipid that might be administered in a pharmaceutical formulation stimulate gallbladder contraction and elevate intestinal levels of bile salt and phospholipid, a likely contributor to the ability of lipid based formulations to enhance the absorption of poorly water-soluble drugs.

TL;DR: Oral and intravenous pharmacokinetic studies of manzamine A in rats indicated the compound to have low metabolic clearance, a reasonably long pharmacokinetics half-life, and good absolute oral bioavailability of 20.6%, which supports the value of these compounds as potential leads for further preclinical assessment and possible development.

TL;DR: Experiments in bile intact rats with the C8 L( alpha) and C18:1 C phase highlighted that the absorption-modifying properties of these phases were influenced by dilution in the endogenous bile milieu, with absorption from L(alpha) phase reducing and increasing in the case of the C18-18 C phase, possibly through the coexistence of L1 and C upon dilution permitting more efficient transfer of solubilized drug.

TL;DR: Five new ozonides with antimalarial efficacy and ADME profiles superior or equal to that of arterolane were identified.

TL;DR: Studies in fasted beagles showed that the solid dispersions afforded a five- to seven-fold improvement in absolute oral bioavailability when compared with the commercially available tablet formulation.