P
Pieter De Bleser
Researcher at Ghent University
Publications - 44
Citations - 3608
Pieter De Bleser is an academic researcher from Ghent University. The author has contributed to research in topics: Hepatic stellate cell & DNA binding site. The author has an hindex of 27, co-authored 41 publications receiving 3152 citations. Previous affiliations of Pieter De Bleser include University of Geneva & Free University of Brussels.
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Journal ArticleDOI
Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche
Johnny Bonnardel,Wouter T’Jonck,Djoere Gaublomme,Robin Browaeys,Charlotte L. Scott,Liesbet Martens,Bavo Vanneste,Sofie De Prijck,Sergei A. Nedospasov,Anna Kremer,Evelien Van Hamme,Peter Borghgraef,Wendy Toussaint,Pieter De Bleser,Inge Mannaerts,Alain Beschin,Leo A. van Grunsven,Bart N. Lambrecht,Tom Taghon,Saskia Lippens,Dirk Elewaut,Yvan Saeys,Martin Guilliams +22 more
TL;DR: It is shown that the Kupffer cell niche is composed of stellate cells, hepatocytes, and endothelial cells that together imprint the liver-specific macrophage identity.
Journal ArticleDOI
Class VI intermediate filament protein nestin is induced during activation of rat hepatic stellate cells
Toshiro Niki,Milos Pekny,Karine Hellemans,Pieter De Bleser,Kit Van Den Berg,Freya Vaeyens,Erik Quartier,Frans Schuit,Albert Geerts +8 more
TL;DR: It is shown that activated stellate cells express nestin, a class VI intermediate filament protein originally identified as a marker for neural stem cells, and that culture activation is a stronger stimulus than in vivo activation by injection of CCl4.
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ORegAnno: an open-access community-driven resource for regulatory annotation.
Obi L. Griffith,Stephen B. Montgomery,Bridget Bernier,Bryan Chu,Katayoon Kasaian,Stein Aerts,Shaun Mahony,Monica C. Sleumer,Mikhail Bilenky,Maximilian Haeussler,Malachi Griffith,Steven M. Gallo,Belinda Giardine,Bart Hooghe,Peter Van Loo,Enrique Blanco,Amy Ticoll,Stuart Lithwick,Elodie Portales-Casamar,Ian J. Donaldson,Gordon Robertson,Claes Wadelius,Pieter De Bleser,D. Vlieghe,Marc S. Halfon,Wyeth W. Wasserman,Ross C. Hardison,Casey M. Bergman,Steven J.M. Jones +28 more
TL;DR: The current release of ORegAnno comprises 30 145 records curated from 922 publications and describing regulatory sequences for over 3853 genes and 465 transcription factors from 19 species.
Journal ArticleDOI
A new generation of JASPAR, the open-access repository for transcription factor binding site profiles
D. Vlieghe,Albin Sandelin,Pieter De Bleser,Kris Vleminckx,Wyeth W. Wasserman,Frans Van Roy,Boris Lenhard +6 more
TL;DR: JASPAR CORE is an expanded version of the original, non-redundant collection of annotated, high-quality matrix-based transcription factor binding profiles, JAS PAR FAM—a collection of familial TFBS models and JASPAR phyloFACTS—a set of matrices computationally derived from statistically overrepresented, evolutionarily conserved regulatory region motifs from mammalian genomes.
Journal ArticleDOI
A histone deacetylase inhibitor, trichostatin A, suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture.
Toshiro Niki,Krista Rombouts,Pieter De Bleser,Karen De Smet,Vera Rogiers,Detlef Schuppan,Minoru Yoshida,Giulio Gabbiani,Albert Geerts +8 more
TL;DR: The antifibrogenic effect of two histone deacetylase inhibitors, sodium butyrate and trichostatin A (TSA), on this cell type in vitro concludes that TSA inhibits transdifferentiation of stellate cells into myofibroblasts by interfering with the level of acetylation of histone H4.