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Xi Zhang
Researcher at Li Ka Shing Faculty of Medicine, University of Hong Kong
Publications - 12
Citations - 1817
Xi Zhang is an academic researcher from Li Ka Shing Faculty of Medicine, University of Hong Kong. The author has contributed to research in topics: Viral replication & Coronavirus. The author has an hindex of 9, co-authored 11 publications receiving 1163 citations. Previous affiliations of Xi Zhang include University of Hong Kong.
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Journal ArticleDOI
Comparative tropism, replication kinetics, and cell damage profiling of SARS-CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and laboratory studies of COVID-19: an observational study.
Hin Chu,Jasper Fuk-Woo Chan,Jasper Fuk-Woo Chan,Terrence Tsz-Tai Yuen,Huiping Shuai,Shuofeng Yuan,Yixin Wang,Bingjie Hu,Cyril C. Y. Yip,Jessica Oi-Ling Tsang,Xiner Huang,Yue Chai,Dong Yang,Yuxin Hou,Kenn Ka-Heng Chik,Xi Zhang,Agnes Yim Fong Fung,Hoi-Wah Tsoi,Jian-Piao Cai,Wan-Mui Chan,Jonathan Daniel Ip,Allen Wing-Ho Chu,Jie Zhou,David Christopher Lung,Kin-Hang Kok,Kelvin K. W. To,Kelvin K. W. To,Owen Tak-Yin Tsang,Kwok-Hung Chan,Kwok-Yung Yuen +29 more
TL;DR: This study presents the first quantitative data for tropism, replication kinetics, and cell damage of SARS-CoV-2, and provides novel insights into the lower incidence of diarrhoea, decreased disease severity, and reduced mortality in patients with COVID-19.
Journal ArticleDOI
Comparative Replication and Immune Activation Profiles of SARS-CoV-2 and SARS-CoV in Human Lungs: An Ex Vivo Study With Implications for the Pathogenesis of COVID-19.
Hin Chu,Jasper Fuk-Woo Chan,Yixin Wang,Terrence Tsz-Tai Yuen,Yue Chai,Yuxin Hou,Huiping Shuai,Dong Yang,Bingjie Hu,Xiner Huang,Xi Zhang,Jian-Piao Cai,Jie Zhou,Shuofeng Yuan,Kin-Hang Kok,Kelvin K. W. To,Kelvin K. W. To,Kelvin K. W. To,Ivy Hau-Yee Chan,Anna Jinxia Zhang,Ko-Yung Sit,Wing-Kuk Au,Kwok-Yung Yuen +22 more
TL;DR: This study provided the first quantitative data on the comparative replication capacity and immune activation profile of SARS-CoV-2 and SARS -CoV infection in human lung tissues and provided important insights on the pathogenesis, high transmissibility, and asymptomatic infection of Sars-Cov-2.
Journal ArticleDOI
Attenuated Interferon and Proinflammatory Response in SARS-CoV-2-Infected Human Dendritic Cells Is Associated With Viral Antagonism of STAT1 Phosphorylation.
Dong Yang,Dong Yang,Hin Chu,Hin Chu,Yuxin Hou,Yuxin Hou,Yue Chai,Yue Chai,Huiping Shuai,Huiping Shuai,Andrew Chak-Yiu Lee,Andrew Chak-Yiu Lee,Xi Zhang,Xi Zhang,Yixin Wang,Yixin Wang,Bingjie Hu,Bingjie Hu,Xiner Huang,Xiner Huang,Terrence Tsz Tai Yuen,Terrence Tsz Tai Yuen,Jian Piao Cai,Jian Piao Cai,Jie Zhou,Jie Zhou,Shuofeng Yuan,Shuofeng Yuan,Anna Jinxia Zhang,Anna Jinxia Zhang,Jasper Fuk-Woo Chan,Kwok-Yung Yuen +31 more
TL;DR: Investigations suggested that this attenuated immune response to SARS-CoV-2 in moDCs was associated with viral antagonism of STAT1 phosphorylation, and these findings may explain the mild and insidious course of COVID-19 until late deterioration.
Journal ArticleDOI
Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells.
Hin Chu,Che-Man Chan,Xi Zhang,Yixin Wang,Shuofeng Yuan,Jie Zhou,Rex Au-Yeung,Kong-Hung Sze,Dong Yang,Huiping Shuai,Yuxin Hou,Cun Li,Xiaoyu Zhao,Vincent Kwok-Man Poon,Sze Pui Leung,Man Lung Yeung,Jinghua Yan,Guangwen Lu,Dong-Yan Jin,George F. Gao,George F. Gao,Jasper Fuk-Woo Chan,Kwok-Yung Yuen +22 more
TL;DR: The capacity of GRP78 to facilitate surface attachment of both a human coronav virus and a phylogenetically related bat coronavirus exemplifies the need for continuous surveillance of the evolution of animal coronaviruses to monitor their potential for human adaptations.
Journal ArticleDOI
Host and viral determinants for efficient SARS-CoV-2 infection of the human lung.
Hin Chu,Bingjie Hu,Xiner Huang,Yue Chai,Dongyan Zhou,Yixin Wang,Huiping Shuai,Dong Yang,Yuxin Hou,Xi Zhang,Terrence Tsz-Tai Yuen,Jian-Piao Cai,Anna Jinxia Zhang,Jie Zhou,Shuofeng Yuan,Kelvin K. W. To,Ivy Hau-Yee Chan,Ko-Yung Sit,Dominic Chi-Chung Foo,Ian Yu-Hong Wong,Ada Tsui-Lin Ng,Tan To Cheung,Simon Law,Wing-Kuk Au,Melinda A. Brindley,Zhiwei Chen,Kin-Hang Kok,Jasper Fuk-Woo Chan,Kwok-Yung Yuen +28 more
TL;DR: In this paper, the authors identify heparan sulfate as an important attachment factor for SARS-CoV-2 infection and show that sialic acids present on ACE2 prevent efficient spike/ACE2-interaction.